Voltammetric behaviour of nitroxazepine in solubilized system and biological fluids

Rajeev Jain, Jahangir Ahmad Rather, Ashish Dwivedi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study reports the development and validation of sensitive and selective assay method for the determination of the antidepressant drug in solubilized system and biological fluids. Solubilized system of different surfactants including cationic, anionic and non-ionic influences the electrochemical response of drug. Addition of cationic surfactant cetrimide to the solution containing drug enhances the peak current signal while anionic and non-ionic showed an opposite effect. The current signal due to reduction process was function of concentration of nitroxazepine, pH, type of surfactant and preconcentration time at the electrode surface. The reduction process is irreversible and adsorption controlled at HMDE. Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for niroxazepine hydrochloride determination. The proposed SWCAdSV and DPCAdSV methods are linear over the concentration range 2.0 × 10-7- 5.0 × 10-9 mol/L and 6.1 × 10-7- 1.0 × 10-8 mol/L with detection limit of 1.62 × 10-10 mo/L and 1.4 × 10-9 mo/L respectively. The method shows good sensitivity, selectivity, accuracy and precision that makes it very suitable for determination of nitroxazepine in pharmaceutical formulation and biological fluids.

Original languageEnglish
Pages (from-to)230-237
Number of pages8
JournalMaterials Science and Engineering C
Volume31
Issue number2
DOIs
Publication statusPublished - Mar 12 2011

    Fingerprint

Keywords

  • Adsorptive stripping voltammetry
  • Biological fluids
  • HMDE
  • Nitroxazepine (Nitrox)
  • Pharmaceutical formulation
  • Solubilized system

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this