Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

Haider A J Al Lawati; Mahmood Al-Azwani; Gouri B. Varma; Fakhr Eldin O Suliman; Salma M Z Al Kindy

doi:10.1039/c2ay05616j

Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

Haider A J Al Lawati^*, Mahmood Al-Azwani, Gouri B. Varma, Fakhr Eldin O Suliman, Salma M Z Al Kindy

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) ₃ ²⁺) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL ^-1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL ^-1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.

Original language	English
Pages (from-to)	773-779
Number of pages	7
Journal	Analytical Methods
Volume	4
Issue number	3
DOIs	https://doi.org/10.1039/c2ay05616j
Publication status	Published - Mar 2012

ASJC Scopus subject areas

Analytical Chemistry
Engineering(all)
Chemical Engineering(all)

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Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device. / Al Lawati, Haider A J; Al-Azwani, Mahmood; Varma, Gouri B.; Suliman, Fakhr Eldin O ; Al Kindy, Salma M Z.

In: Analytical Methods, Vol. 4, No. 3, 03.2012, p. 773-779.

Research output: Contribution to journal › Article › peer-review

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abstract = "A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.",

author = "{Al Lawati}, {Haider A J} and Mahmood Al-Azwani and Varma, {Gouri B.} and Suliman, {Fakhr Eldin O} and {Al Kindy}, {Salma M Z}",

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AU - Al Lawati, Haider A J

AU - Al-Azwani, Mahmood

AU - Varma, Gouri B.

AU - Suliman, Fakhr Eldin O

AU - Al Kindy, Salma M Z

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AB - A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.

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Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

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