Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

Haider A J Al Lawati; Mahmood Al-Azwani; Gouri B. Varma; Fakhr Eldin O Suliman; Salma M Z Al Kindy

doi:10.1039/c2ay05616j

Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

Haider A J Al Lawati, Mahmood Al-Azwani, Gouri B. Varma, Fakhr Eldin O Suliman, Salma M Z Al Kindy

Chemistry

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) ₃ ²⁺) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL ^-1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL ^-1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.

Original language	English
Pages (from-to)	773-779
Number of pages	7
Journal	Analytical Methods
Volume	4
Issue number	3
DOIs	https://doi.org/10.1039/c2ay05616j
Publication status	Published - Mar 2012

ASJC Scopus subject areas

Analytical Chemistry
Engineering(all)
Chemical Engineering(all)

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Al Lawati, H. A. J., Al-Azwani, M., Varma, G. B., Suliman, F. E. O., & Al Kindy, S. M. Z. (2012). Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device. Analytical Methods, 4(3), 773-779. https://doi.org/10.1039/c2ay05616j

Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device. / Al Lawati, Haider A J; Al-Azwani, Mahmood; Varma, Gouri B.; Suliman, Fakhr Eldin O ; Al Kindy, Salma M Z.

In: Analytical Methods, Vol. 4, No. 3, 03.2012, p. 773-779.

Research output: Contribution to journal › Article

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abstract = "A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.",

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