Abstract
A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.
| Original language | English |
|---|---|
| Pages (from-to) | 773-779 |
| Number of pages | 7 |
| Journal | Analytical Methods |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2012 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Engineering(all)
- Chemical Engineering(all)
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Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device. / Al Lawati, Haider A J; Al-Azwani, Mahmood; Varma, Gouri B.; Suliman, Fakhr Eldin O; Al Kindy, Salma M Z.
In: Analytical Methods, Vol. 4, No. 3, 03.2012, p. 773-779.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device
AU - Al Lawati, Haider A J
AU - Al-Azwani, Mahmood
AU - Varma, Gouri B.
AU - Suliman, Fakhr Eldin O
AU - Al Kindy, Salma M Z
PY - 2012/3
Y1 - 2012/3
N2 - A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.
AB - A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.
UR - http://www.scopus.com/inward/record.url?scp=84857873444&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857873444&partnerID=8YFLogxK
U2 - 10.1039/c2ay05616j
DO - 10.1039/c2ay05616j
M3 - Article
AN - SCOPUS:84857873444
VL - 4
SP - 773
EP - 779
JO - Analytical Methods
JF - Analytical Methods
SN - 1759-9660
IS - 3
ER -