Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device

Haider A.J. Al Lawati*, Mahmood Al-Azwani, Gouri B. Varma, Fakhr Eldin O. Suliman, Salma M.Z. Al Kindy

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

10 اقتباسات (Scopus)

ملخص

A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.

اللغة الأصليةEnglish
الصفحات (من إلى)773-779
عدد الصفحات7
دوريةAnalytical Methods
مستوى الصوت4
رقم الإصدار3
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مارس 2012

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device'. فهما يشكلان معًا بصمة فريدة.

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