TY - JOUR
T1 - Towards an ideal method for analysis of lisinopril in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii)-peroxydisulfate chemiluminescence system in a two chip device
AU - Al Lawati, Haider A.J.
AU - Al-Azwani, Mahmood
AU - Varma, Gouri B.
AU - Suliman, Fakhr Eldin O.
AU - Al Kindy, Salma M.Z.
PY - 2012/3
Y1 - 2012/3
N2 - A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.
AB - A novel, rapid, selective and sensitive method has been developed for analysis of lisinopril (LIS) in pharmaceutical formulations using a tris(2,2′-bipyridyl)-ruthenium(ii) (Ru(bipy) 3 2+) peroxydisulfate chemiluminescence (CL) system in a two chip device. The parameters that influence the CL signal intensity were carefully optimized. These include pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve between 0.25 and 50.0 μg mL -1 was obtained. About 180 samples were analyzed per hour while the detection limit was found to be 0.067 μg mL -1. The method was applied for analysis of LIS in pharmaceutical products and was found to be free from interferences of acid-induced degradation (AID) products and other ingredients usually present in these preparations.
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U2 - 10.1039/c2ay05616j
DO - 10.1039/c2ay05616j
M3 - Article
AN - SCOPUS:84857873444
SN - 1759-9660
VL - 4
SP - 773
EP - 779
JO - Analytical Methods
JF - Analytical Methods
IS - 3
ER -