The shady side of sunlight: Current understanding of the mechanisms underlying UV-induction of skin cancers

Alison Trappey, Augusta Fernando, Rajiv Gaur, Madhwa Raj, Allal Ouhtit

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The incidence of skin cancer has been rising at an astonishing rate, particularly that of the deadliest skin cancer, melanoma. While the molecular mechanisms of sunlight ultraviolet radiation (UV)-induced non-melanoma skin cancer (NMSC) have been well documented, there is a major gap in our current knowledge of how UV initiates melanoma. However, the components of the retinoblastoma (Rb) pathway, the p53 and the p16 pathways are considered the major targets of UV-induced NMSC and melanoma, respectively. Our recent study has revealed that these two pathways coordinate the early responses to UV radiation in the skin. Here, we review the value of studies targeting these early events of skin carcinogenesis, with specific focus on the critical role of the components of the Rb pathway.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalFrontiers in Bioscience - Scholar
Volume2 S
Issue number1
Publication statusPublished - Jan 1 2010

Keywords

  • Apoptosis
  • Cell Proliferation
  • P16
  • P53
  • Rb
  • Review
  • Skin Cancer
  • Sunlight Ultraviolet Radiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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