TY - JOUR
T1 - The shady side of sunlight
T2 - Current understanding of the mechanisms underlying UV-induction of skin cancers
AU - Trappey, Alison
AU - Fernando, Augusta
AU - Gaur, Rajiv
AU - Raj, Madhwa
AU - Ouhtit, Allal
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The incidence of skin cancer has been rising at an astonishing rate, particularly that of the deadliest skin cancer, melanoma. While the molecular mechanisms of sunlight ultraviolet radiation (UV)-induced non-melanoma skin cancer (NMSC) have been well documented, there is a major gap in our current knowledge of how UV initiates melanoma. However, the components of the retinoblastoma (Rb) pathway, the p53 and the p16 pathways are considered the major targets of UV-induced NMSC and melanoma, respectively. Our recent study has revealed that these two pathways coordinate the early responses to UV radiation in the skin. Here, we review the value of studies targeting these early events of skin carcinogenesis, with specific focus on the critical role of the components of the Rb pathway.
AB - The incidence of skin cancer has been rising at an astonishing rate, particularly that of the deadliest skin cancer, melanoma. While the molecular mechanisms of sunlight ultraviolet radiation (UV)-induced non-melanoma skin cancer (NMSC) have been well documented, there is a major gap in our current knowledge of how UV initiates melanoma. However, the components of the retinoblastoma (Rb) pathway, the p53 and the p16 pathways are considered the major targets of UV-induced NMSC and melanoma, respectively. Our recent study has revealed that these two pathways coordinate the early responses to UV radiation in the skin. Here, we review the value of studies targeting these early events of skin carcinogenesis, with specific focus on the critical role of the components of the Rb pathway.
KW - Apoptosis
KW - Cell Proliferation
KW - P16
KW - P53
KW - Rb
KW - Review
KW - Skin Cancer
KW - Sunlight Ultraviolet Radiation
UR - http://www.scopus.com/inward/record.url?scp=77957322559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957322559&partnerID=8YFLogxK
U2 - 10.2741/s42
DO - 10.2741/s42
M3 - Article
C2 - 20036925
AN - SCOPUS:77957322559
SN - 1945-0516
VL - 2 S
SP - 11
EP - 17
JO - Frontiers in Bioscience - Scholar
JF - Frontiers in Bioscience - Scholar
IS - 1
ER -