TY - JOUR
T1 - Selectively cytotoxic diterpenes from Euphorbia poisonii
AU - Fatope, Majekodunmi O.
AU - Zeng, Lu
AU - Ohayaga, Joseph E.
AU - Shi, Guoen
AU - McLaughlin, Jerry L.
PY - 1996/2/16
Y1 - 1996/2/16
N2 - Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1, 2, 4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.
AB - Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1, 2, 4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.
UR - http://www.scopus.com/inward/record.url?scp=0030025030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030025030&partnerID=8YFLogxK
U2 - 10.1021/jm950509i
DO - 10.1021/jm950509i
M3 - Article
C2 - 8632402
AN - SCOPUS:0030025030
SN - 0022-2623
VL - 39
SP - 1005
EP - 1008
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 4
ER -