Selectively cytotoxic diterpenes from Euphorbia poisonii

Majekodunmi O. Fatope, Lu Zeng, Joseph E. Ohayaga, Guoen Shi, Jerry L. McLaughlin

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1, 2, 4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.

Original languageEnglish
Pages (from-to)1005-1008
Number of pages4
JournalJournal of Medicinal Chemistry
Volume39
Issue number4
DOIs
Publication statusPublished - Feb 16 1996

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Euphorbia
Diterpenes
Cells
Euphorbiaceae
Latex
Cytotoxicity
Fractionation
Bioactivity
Tumor Cell Line
Doxorubicin
Tumors
Esters
Carcinoma
Kidney
Cell Line

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Selectively cytotoxic diterpenes from Euphorbia poisonii. / Fatope, Majekodunmi O.; Zeng, Lu; Ohayaga, Joseph E.; Shi, Guoen; McLaughlin, Jerry L.

In: Journal of Medicinal Chemistry, Vol. 39, No. 4, 16.02.1996, p. 1005-1008.

Research output: Contribution to journalArticle

Fatope, MO, Zeng, L, Ohayaga, JE, Shi, G & McLaughlin, JL 1996, 'Selectively cytotoxic diterpenes from Euphorbia poisonii', Journal of Medicinal Chemistry, vol. 39, no. 4, pp. 1005-1008. https://doi.org/10.1021/jm950509i
Fatope, Majekodunmi O. ; Zeng, Lu ; Ohayaga, Joseph E. ; Shi, Guoen ; McLaughlin, Jerry L. / Selectively cytotoxic diterpenes from Euphorbia poisonii. In: Journal of Medicinal Chemistry. 1996 ; Vol. 39, No. 4. pp. 1005-1008.
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