ملخص
Bioactivity-guided fractionation of the latex of Euphorbia poisonii Pax. (Euphorbiaceae) led to the isolation and characterization of a new tigliane diterpene, 12-deoxyphorbol 13-(9,10-methylene)undecanoate (3), together with five known diterpenes (1, 2, 4-6). When evaluated for cytotoxicity in a panel of six human solid tumor cell lines, the diterpene esters, 1-3, 5, and 6, were selectively cytotoxic for the human kidney carcinoma (A-498) cell line with potencies for 2 and 3 exceeding that of adriamycin by ten thousand times. Details of the isolations, structural analyses, and cytotoxic activities are described.
اللغة الأصلية | English |
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الصفحات (من إلى) | 1005-1008 |
عدد الصفحات | 4 |
دورية | Journal of Medicinal Chemistry |
مستوى الصوت | 39 |
رقم الإصدار | 4 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - فبراير 16 1996 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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