Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East

Kadhim Sulaiman; Ibrahim Al-Zakwani; Prashanth Panduranga; Jassim Al-Suwaidi; Alawi A. Alsheikh-Ali; Wael Al Mahmeed; Haitham Amin; Ahmed Al-Mutarreb; Khalid Alhabib; Jawad Al-Lawati; Mohammed Zubaid

doi:10.1177/0003319711407304

Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East

Kadhim Sulaiman^*, Ibrahim Al-Zakwani, Prashanth Panduranga, Jassim Al-Suwaidi, Alawi A. Alsheikh-Ali, Wael Al Mahmeed, Haitham Amin, Ahmed Al-Mutarreb, Khalid Alhabib, Jawad Al-Lawati, Mohammed Zubaid

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.

Original language	English
Pages (from-to)	24-29
Number of pages	6
Journal	Angiology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1177/0003319711407304
Publication status	Published - Jan 2012

Keywords

Middle East
acute coronary syndrome
cardiogenic shock
in-hospital mortality
white blood cells

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1177/0003319711407304

Cite this

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title = "Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East",

abstract = "We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.",

keywords = "Middle East, acute coronary syndrome, cardiogenic shock, in-hospital mortality, white blood cells",

author = "Kadhim Sulaiman and Ibrahim Al-Zakwani and Prashanth Panduranga and Jassim Al-Suwaidi and Alsheikh-Ali, {Alawi A.} and Mahmeed, {Wael Al} and Haitham Amin and Ahmed Al-Mutarreb and Khalid Alhabib and Jawad Al-Lawati and Mohammed Zubaid",

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AU - Sulaiman, Kadhim

AU - Al-Zakwani, Ibrahim

AU - Panduranga, Prashanth

AU - Al-Suwaidi, Jassim

AU - Alsheikh-Ali, Alawi A.

AU - Mahmeed, Wael Al

AU - Amin, Haitham

AU - Al-Mutarreb, Ahmed

AU - Alhabib, Khalid

AU - Al-Lawati, Jawad

AU - Zubaid, Mohammed

PY - 2012/1

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N2 - We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.

AB - We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.

KW - Middle East

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KW - in-hospital mortality

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Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East

Abstract

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