TY - JOUR
T1 - Relationship between white blood cell count and in-hospital outcomes in acute coronary syndrome patients from the Middle East
AU - Sulaiman, Kadhim
AU - Al-Zakwani, Ibrahim
AU - Panduranga, Prashanth
AU - Al-Suwaidi, Jassim
AU - Alsheikh-Ali, Alawi A.
AU - Mahmeed, Wael Al
AU - Amin, Haitham
AU - Al-Mutarreb, Ahmed
AU - Alhabib, Khalid
AU - Al-Lawati, Jawad
AU - Zubaid, Mohammed
PY - 2012/1
Y1 - 2012/1
N2 - We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.
AB - We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (×109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P =.030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P <.001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P =.021) and 65% (95% CI: 1.17-2.32; P =.004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.
KW - Middle East
KW - acute coronary syndrome
KW - cardiogenic shock
KW - in-hospital mortality
KW - white blood cells
UR - http://www.scopus.com/inward/record.url?scp=82955224973&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955224973&partnerID=8YFLogxK
U2 - 10.1177/0003319711407304
DO - 10.1177/0003319711407304
M3 - Article
C2 - 21555308
AN - SCOPUS:82955224973
SN - 0003-3197
VL - 63
SP - 24
EP - 29
JO - Angiology
JF - Angiology
IS - 1
ER -