Lamotrigene and vigabatrin in intractable seizures in children

R. L. Koul, G. R. Aithala, R. M. Joshi, M. S. Elbualy, K. Al Riyami

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Twenty seven children with intractable seizures in the age group of 5 months - 14 years were treated with vigabatrin (VGB) and Lamotrigene (LTG) as an add-on therapy. Fourteen children (6M:8F) were given VGB and thirteen children (9M:4F) received LTG. The drug selection was made according to the type of seizures and associated neurological abnormalities. Attempt was made to exclude children with progressive neurologic disorders or severe systemic disease. EEG, CT scan head and relevant metabolic work up was done in all. VGB was found to be most effective in seizures associated with tuberous sclerosis. It was always useful in infantile spasm (IS) and tonic clonic (TC) seizures. LTG was effective in complex partial seizure (CPS) and TC seizures with myoclonus.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalNeurology India
Volume46
Issue number2
Publication statusPublished - 1998

Fingerprint

Vigabatrin
Seizures
Infantile Spasms
Myoclonus
Tuberous Sclerosis
Nervous System Diseases
Electroencephalography
Age Groups
Head
Pharmaceutical Preparations

Keywords

  • Intractable seizures
  • Lamotrigene
  • Vigabatrin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Koul, R. L., Aithala, G. R., Joshi, R. M., Elbualy, M. S., & Al Riyami, K. (1998). Lamotrigene and vigabatrin in intractable seizures in children. Neurology India, 46(2), 130-133.

Lamotrigene and vigabatrin in intractable seizures in children. / Koul, R. L.; Aithala, G. R.; Joshi, R. M.; Elbualy, M. S.; Al Riyami, K.

In: Neurology India, Vol. 46, No. 2, 1998, p. 130-133.

Research output: Contribution to journalArticle

Koul, RL, Aithala, GR, Joshi, RM, Elbualy, MS & Al Riyami, K 1998, 'Lamotrigene and vigabatrin in intractable seizures in children', Neurology India, vol. 46, no. 2, pp. 130-133.
Koul RL, Aithala GR, Joshi RM, Elbualy MS, Al Riyami K. Lamotrigene and vigabatrin in intractable seizures in children. Neurology India. 1998;46(2):130-133.
Koul, R. L. ; Aithala, G. R. ; Joshi, R. M. ; Elbualy, M. S. ; Al Riyami, K. / Lamotrigene and vigabatrin in intractable seizures in children. In: Neurology India. 1998 ; Vol. 46, No. 2. pp. 130-133.
@article{242ab072543f4bb7936e05ca3ea498cc,
title = "Lamotrigene and vigabatrin in intractable seizures in children",
abstract = "Twenty seven children with intractable seizures in the age group of 5 months - 14 years were treated with vigabatrin (VGB) and Lamotrigene (LTG) as an add-on therapy. Fourteen children (6M:8F) were given VGB and thirteen children (9M:4F) received LTG. The drug selection was made according to the type of seizures and associated neurological abnormalities. Attempt was made to exclude children with progressive neurologic disorders or severe systemic disease. EEG, CT scan head and relevant metabolic work up was done in all. VGB was found to be most effective in seizures associated with tuberous sclerosis. It was always useful in infantile spasm (IS) and tonic clonic (TC) seizures. LTG was effective in complex partial seizure (CPS) and TC seizures with myoclonus.",
keywords = "Intractable seizures, Lamotrigene, Vigabatrin",
author = "Koul, {R. L.} and Aithala, {G. R.} and Joshi, {R. M.} and Elbualy, {M. S.} and {Al Riyami}, K.",
year = "1998",
language = "English",
volume = "46",
pages = "130--133",
journal = "Neurology India",
issn = "0028-3886",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "2",

}

TY - JOUR

T1 - Lamotrigene and vigabatrin in intractable seizures in children

AU - Koul, R. L.

AU - Aithala, G. R.

AU - Joshi, R. M.

AU - Elbualy, M. S.

AU - Al Riyami, K.

PY - 1998

Y1 - 1998

N2 - Twenty seven children with intractable seizures in the age group of 5 months - 14 years were treated with vigabatrin (VGB) and Lamotrigene (LTG) as an add-on therapy. Fourteen children (6M:8F) were given VGB and thirteen children (9M:4F) received LTG. The drug selection was made according to the type of seizures and associated neurological abnormalities. Attempt was made to exclude children with progressive neurologic disorders or severe systemic disease. EEG, CT scan head and relevant metabolic work up was done in all. VGB was found to be most effective in seizures associated with tuberous sclerosis. It was always useful in infantile spasm (IS) and tonic clonic (TC) seizures. LTG was effective in complex partial seizure (CPS) and TC seizures with myoclonus.

AB - Twenty seven children with intractable seizures in the age group of 5 months - 14 years were treated with vigabatrin (VGB) and Lamotrigene (LTG) as an add-on therapy. Fourteen children (6M:8F) were given VGB and thirteen children (9M:4F) received LTG. The drug selection was made according to the type of seizures and associated neurological abnormalities. Attempt was made to exclude children with progressive neurologic disorders or severe systemic disease. EEG, CT scan head and relevant metabolic work up was done in all. VGB was found to be most effective in seizures associated with tuberous sclerosis. It was always useful in infantile spasm (IS) and tonic clonic (TC) seizures. LTG was effective in complex partial seizure (CPS) and TC seizures with myoclonus.

KW - Intractable seizures

KW - Lamotrigene

KW - Vigabatrin

UR - http://www.scopus.com/inward/record.url?scp=0031851731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031851731&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 130

EP - 133

JO - Neurology India

JF - Neurology India

SN - 0028-3886

IS - 2

ER -