Lamotrigene and vigabatrin in intractable seizures in children

Twenty seven children with intractable seizures in the age group of 5 months - 14 years were treated with vigabatrin (VGB) and Lamotrigene (LTG) as an add-on therapy. Fourteen children (6M:8F) were given VGB and thirteen children (9M:4F) received LTG. The drug selection was made according to the type of seizures and associated neurological abnormalities. Attempt was made to exclude children with progressive neurologic disorders or severe systemic disease. EEG, CT scan head and relevant metabolic work up was done in all. VGB was found to be most effective in seizures associated with tuberous sclerosis. It was always useful in infantile spasm (IS) and tonic clonic (TC) seizures. LTG was effective in complex partial seizure (CPS) and TC seizures with myoclonus.