Innate and adaptive immune genes associated with mers-cov infection in dromedaries

Sara Lado, Jean P. Elbers, Martin Plasil, Tom Loney, Pia Weidinger, Jeremy V. Camp, Jolanta Kolodziejek, Jan Futas, Dafalla A. Kannan, Pablo Orozco-Terwengel, Petr Horin, Norbert Nowotny, Pamela A. Burger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

Original languageEnglish
Article number1291
JournalCells
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2021
Externally publishedYes

Keywords

  • Coronavirus
  • Immune response genes
  • In-solution hybridization cap-ture
  • Old World camels
  • Zoonosis

ASJC Scopus subject areas

  • Medicine(all)

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