Innate and adaptive immune genes associated with mers-cov infection in dromedaries

Sara Lado; Jean P. Elbers; Martin Plasil; Tom Loney; Pia Weidinger; Jeremy V. Camp; Jolanta Kolodziejek; Jan Futas; Dafalla A. Kannan; Pablo Orozco-Terwengel; Petr Horin; Norbert Nowotny; Pamela A. Burger

doi:10.3390/cells10061291

Innate and adaptive immune genes associated with mers-cov infection in dromedaries

Sara Lado, Jean P. Elbers, Martin Plasil, Tom Loney, Pia Weidinger, Jeremy V. Camp, Jolanta Kolodziejek, Jan Futas, Dafalla A. Kannan, Pablo Orozco-Terwengel, Petr Horin, Norbert Nowotny, Pamela A. Burger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

Original language	English
Article number	1291
Journal	Cells
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/cells10061291
Publication status	Published - Jun 2021
Externally published	Yes

Keywords

Coronavirus
Immune response genes
In-solution hybridization cap-ture
Old World camels
Zoonosis

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells10061291

Cite this

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title = "Innate and adaptive immune genes associated with mers-cov infection in dromedaries",

abstract = "The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.",

keywords = "Coronavirus, Immune response genes, In-solution hybridization cap-ture, Old World camels, Zoonosis",

author = "Sara Lado and Elbers, {Jean P.} and Martin Plasil and Tom Loney and Pia Weidinger and Camp, {Jeremy V.} and Jolanta Kolodziejek and Jan Futas and Kannan, {Dafalla A.} and Pablo Orozco-Terwengel and Petr Horin and Norbert Nowotny and Burger, {Pamela A.}",

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doi = "10.3390/cells10061291",

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AU - Lado, Sara

AU - Elbers, Jean P.

AU - Plasil, Martin

AU - Loney, Tom

AU - Weidinger, Pia

AU - Camp, Jeremy V.

AU - Kolodziejek, Jolanta

AU - Futas, Jan

AU - Kannan, Dafalla A.

AU - Orozco-Terwengel, Pablo

AU - Horin, Petr

AU - Nowotny, Norbert

AU - Burger, Pamela A.

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AB - The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.

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Innate and adaptive immune genes associated with mers-cov infection in dromedaries

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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