TY - JOUR
T1 - Innate and adaptive immune genes associated with mers-cov infection in dromedaries
AU - Lado, Sara
AU - Elbers, Jean P.
AU - Plasil, Martin
AU - Loney, Tom
AU - Weidinger, Pia
AU - Camp, Jeremy V.
AU - Kolodziejek, Jolanta
AU - Futas, Jan
AU - Kannan, Dafalla A.
AU - Orozco-Terwengel, Pablo
AU - Horin, Petr
AU - Nowotny, Norbert
AU - Burger, Pamela A.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6
Y1 - 2021/6
N2 - The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.
AB - The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 im-mune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previ-ously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.
KW - Coronavirus
KW - Immune response genes
KW - In-solution hybridization cap-ture
KW - Old World camels
KW - Zoonosis
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U2 - 10.3390/cells10061291
DO - 10.3390/cells10061291
M3 - Article
C2 - 34070971
AN - SCOPUS:85107402321
SN - 2073-4409
VL - 10
JO - Cells
JF - Cells
IS - 6
M1 - 1291
ER -