Infections caused by bornaviruses

Ralf Dürrwald, Norbert Nowotny, Martin Beer, Jens H. Kuhn

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Bornaviruses (Mononegavirales: Bornaviridae) form enveloped virions with nonsegmented, single-stranded negative-sense genomes (~8.9 kilobases). They naturally infect mammals (e.g., bicolored white-toothed shrews [Crocidura leucodon], equids, sheep, variegated squirrels [Sciurus variegatoides] but rarely other mammals including humans) and a wide variety of birds and snakes. Bornaviruses have unique characteristics, such as 1) replication in the nucleus using cellular splicing machinery for generation of mRNAs and integrating bornaviral elements into the host-cell genome; 2) genome trimming for generation of RNAs that probably do not trigger innate immune responses in infected cells; and 3) suppression of apoptosis in infected cells mediated by the accessory protein (X), leading to persistent noncytolytic infection.

Original languageEnglish
Title of host publicationClinical Virology
Publisherwiley
Pages1395-1407
Number of pages13
ISBN (Electronic)9781683670674
ISBN (Print)9781555819422
DOIs
Publication statusPublished - Mar 7 2016
Externally publishedYes

Keywords

  • Animals
  • Antiinflammatory treatment
  • Borna disease
  • Epidemiological factors
  • Human bornavirus infections
  • Immunopathogenesis
  • Laboratory diagnosis
  • Virology

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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