Infections caused by bornaviruses

Ralf Dürrwald, Norbert Nowotny, Martin Beer, Jens H. Kuhn

نتاج البحث: Chapter

4 اقتباسات (Scopus)

ملخص

Bornaviruses (Mononegavirales: Bornaviridae) form enveloped virions with nonsegmented, single-stranded negative-sense genomes (~8.9 kilobases). They naturally infect mammals (e.g., bicolored white-toothed shrews [Crocidura leucodon], equids, sheep, variegated squirrels [Sciurus variegatoides] but rarely other mammals including humans) and a wide variety of birds and snakes. Bornaviruses have unique characteristics, such as 1) replication in the nucleus using cellular splicing machinery for generation of mRNAs and integrating bornaviral elements into the host-cell genome; 2) genome trimming for generation of RNAs that probably do not trigger innate immune responses in infected cells; and 3) suppression of apoptosis in infected cells mediated by the accessory protein (X), leading to persistent noncytolytic infection.

اللغة الأصليةEnglish
عنوان منشور المضيفClinical Virology
ناشرwiley
الصفحات1395-1407
عدد الصفحات13
رقم المعيار الدولي للكتب (الإلكتروني)9781683670674
رقم المعيار الدولي للكتب (المطبوع)9781555819422
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مارس 7 2016
منشور خارجيًانعم

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