HIV-1 clade-C-associated "ALS"-like disorder: First report from India

Sanjib Sinha, Thomas Mathews, G. R. Arunodaya, Nagadenahalli B. Siddappa, Udaykumar Ranga, A. Desai, V. Ravi, A. B. Taly

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalJournal of the Neurological Sciences
Volume224
Issue number1-2
DOIs
Publication statusPublished - Sep 15 2004

Fingerprint

Amyotrophic Lateral Sclerosis
HIV-1
India
Motor Neuron Disease
Upper Extremity
HIV
Nevirapine
Stretch Reflex
Muscles
Lamivudine
Zidovudine
Neural Conduction
Heterosexuality
Muscle Strength
Hematologic Tests
Denervation
Extremities
Urine

Keywords

  • Amyotrophic lateral sclerosis
  • HIV-1
  • Motor neuron disease
  • Subtype-C

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

HIV-1 clade-C-associated "ALS"-like disorder : First report from India. / Sinha, Sanjib; Mathews, Thomas; Arunodaya, G. R.; Siddappa, Nagadenahalli B.; Ranga, Udaykumar; Desai, A.; Ravi, V.; Taly, A. B.

In: Journal of the Neurological Sciences, Vol. 224, No. 1-2, 15.09.2004, p. 97-100.

Research output: Contribution to journalArticle

Sinha, S, Mathews, T, Arunodaya, GR, Siddappa, NB, Ranga, U, Desai, A, Ravi, V & Taly, AB 2004, 'HIV-1 clade-C-associated "ALS"-like disorder: First report from India', Journal of the Neurological Sciences, vol. 224, no. 1-2, pp. 97-100. https://doi.org/10.1016/j.jns.2004.06.006
Sinha, Sanjib ; Mathews, Thomas ; Arunodaya, G. R. ; Siddappa, Nagadenahalli B. ; Ranga, Udaykumar ; Desai, A. ; Ravi, V. ; Taly, A. B. / HIV-1 clade-C-associated "ALS"-like disorder : First report from India. In: Journal of the Neurological Sciences. 2004 ; Vol. 224, No. 1-2. pp. 97-100.
@article{1ed4a823b21a4af7bcb4b9078d50d873,
title = "HIV-1 clade-C-associated {"}ALS{"}-like disorder: First report from India",
abstract = "A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10{\%} and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of {"}ALS{"}-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.",
keywords = "Amyotrophic lateral sclerosis, HIV-1, Motor neuron disease, Subtype-C",
author = "Sanjib Sinha and Thomas Mathews and Arunodaya, {G. R.} and Siddappa, {Nagadenahalli B.} and Udaykumar Ranga and A. Desai and V. Ravi and Taly, {A. B.}",
year = "2004",
month = "9",
day = "15",
doi = "10.1016/j.jns.2004.06.006",
language = "English",
volume = "224",
pages = "97--100",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - HIV-1 clade-C-associated "ALS"-like disorder

T2 - First report from India

AU - Sinha, Sanjib

AU - Mathews, Thomas

AU - Arunodaya, G. R.

AU - Siddappa, Nagadenahalli B.

AU - Ranga, Udaykumar

AU - Desai, A.

AU - Ravi, V.

AU - Taly, A. B.

PY - 2004/9/15

Y1 - 2004/9/15

N2 - A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.

AB - A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.

KW - Amyotrophic lateral sclerosis

KW - HIV-1

KW - Motor neuron disease

KW - Subtype-C

UR - http://www.scopus.com/inward/record.url?scp=4644303082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644303082&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2004.06.006

DO - 10.1016/j.jns.2004.06.006

M3 - Article

C2 - 15450778

AN - SCOPUS:4644303082

VL - 224

SP - 97

EP - 100

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -