HIV-1 clade-C-associated "ALS"-like disorder: First report from India

Sanjib Sinha, Thomas Mathews, G. R. Arunodaya, Nagadenahalli B. Siddappa, Udaykumar Ranga, A. Desai, V. Ravi, A. B. Taly

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

24 اقتباسات (Scopus)

ملخص

A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.

اللغة الأصليةEnglish
الصفحات (من إلى)97-100
عدد الصفحات4
دوريةJournal of the Neurological Sciences
مستوى الصوت224
رقم الإصدار1-2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - سبتمبر 15 2004
منشور خارجيًانعم

ASJC Scopus subject areas

  • ???subjectarea.asjc.2800.2808???
  • ???subjectarea.asjc.2700.2728???

بصمة

أدرس بدقة موضوعات البحث “HIV-1 clade-C-associated "ALS"-like disorder: First report from India'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا