TY - JOUR
T1 - HIV-1 clade-C-associated "ALS"-like disorder
T2 - First report from India
AU - Sinha, Sanjib
AU - Mathews, Thomas
AU - Arunodaya, G. R.
AU - Siddappa, Nagadenahalli B.
AU - Ranga, Udaykumar
AU - Desai, A.
AU - Ravi, V.
AU - Taly, A. B.
PY - 2004/9/15
Y1 - 2004/9/15
N2 - A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.
AB - A patient of ALS-like disorder in an HIV-1 clade-C-infected heterosexual male is being reported. A 37-year-old gentleman presented with subacute, progressive asymmetrical onset of weakness and wasting of upper limbs associated with brisk muscle stretch reflexes and without any sensory or sphincter involvement. While nerve conduction tests were normal, the EMG of proximal and distal limb muscles on both sides revealed evidence of denervation and reinnervation. Routine blood and urine tests and investigations for underlying causes of motor neuron disease were noncontributory. He was HIV-1, subtype clade C seropositive. A diagnosis of HIV-related anterior horn cell disease was considered and zidovudine, lamivudine and nevirapine were started. After 1 month, there was a subjective improvement of 10% and objective improvement in strength of muscles of proximal upper limb on both sides by one grade power on MRC scale. Reports of amyotrophic lateral sclerosis (ALS)-like illness in HIV are sparse. The reversibility of "ALS"-like features in this subgroup of patients might offer an insight into the pathogenesis of amyotrophic lateral sclerosis. This is a first report of ALS-like illness caused by subtype C of HIV-1 strain.
KW - Amyotrophic lateral sclerosis
KW - HIV-1
KW - Motor neuron disease
KW - Subtype-C
UR - http://www.scopus.com/inward/record.url?scp=4644303082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644303082&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2004.06.006
DO - 10.1016/j.jns.2004.06.006
M3 - Article
C2 - 15450778
AN - SCOPUS:4644303082
SN - 0022-510X
VL - 224
SP - 97
EP - 100
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -