Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates

Hamza Ali Babiker, Alison M. Creasey, Riad A L Bayoumi, David Walliker, David E. Arnot

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41 Citations (Scopus)

Abstract

Isolates of Plasmodium falciparum from a Sudanese village have been collected as part of a study of parasite genetic diversity during seasonal malaria epidemics. The sensitivity in vitro to chloroquine, pyrimethamine and mefloquine of these isolates has been determined. To assess the utility of pulse field gel chromosome separations in isolate characterization, 18 samples from individual patients in a single village were studied using this technique. Extensive variation in chromosome size was detected, no 2 isolates having identical molecular karyotypes. No multidrug resistance (mdr) gene amplification polymorphisms were detected in either chloroquine-resistant or chloroquine-sensitive isolates in this sample.

Original languageEnglish
Pages (from-to)578-583
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume85
Issue number5
DOIs
Publication statusPublished - 1991

Fingerprint

Sudan
Chloroquine
Plasmodium falciparum
Karyotype
Drug Resistance
Genotype
Chromosomes
Mefloquine
MDR Genes
Pyrimethamine
Gene Amplification
Malaria
Parasites
Gels

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates. / Babiker, Hamza Ali; Creasey, Alison M.; Bayoumi, Riad A L; Walliker, David; Arnot, David E.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 85, No. 5, 1991, p. 578-583.

Research output: Contribution to journalArticle

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