Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates

Hamza Ali Babiker; Alison M. Creasey; Riad A.L. Bayoumi; David Walliker; David E. Arnot

doi:10.1016/0035-9203(91)90349-4

Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates

Hamza Ali Babiker^*, Alison M. Creasey, Riad A.L. Bayoumi, David Walliker, David E. Arnot

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Isolates of Plasmodium falciparum from a Sudanese village have been collected as part of a study of parasite genetic diversity during seasonal malaria epidemics. The sensitivity in vitro to chloroquine, pyrimethamine and mefloquine of these isolates has been determined. To assess the utility of pulse field gel chromosome separations in isolate characterization, 18 samples from individual patients in a single village were studied using this technique. Extensive variation in chromosome size was detected, no 2 isolates having identical molecular karyotypes. No multidrug resistance (mdr) gene amplification polymorphisms were detected in either chloroquine-resistant or chloroquine-sensitive isolates in this sample.

Original language	English
Pages (from-to)	578-583
Number of pages	6
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	85
Issue number	5
DOIs	https://doi.org/10.1016/0035-9203(91)90349-4
Publication status	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0035-9203(91)90349-4

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Babiker, H. A., Creasey, A. M., Bayoumi, R. A. L., Walliker, D., & Arnot, D. E. (1991). Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85(5), 578-583. https://doi.org/10.1016/0035-9203(91)90349-4

Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates. / Babiker, Hamza Ali; Creasey, Alison M.; Bayoumi, Riad A.L. et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 85, No. 5, 1991, p. 578-583.

Research output: Contribution to journal › Article › peer-review

Babiker, HA, Creasey, AM, Bayoumi, RAL, Walliker, D & Arnot, DE 1991, 'Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 85, no. 5, pp. 578-583. https://doi.org/10.1016/0035-9203(91)90349-4

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Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates

Abstract

ASJC Scopus subject areas

UN SDGs

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