TY - JOUR
T1 - Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype of recent isolates
AU - Babiker, Hamza Ali
AU - Creasey, Alison M.
AU - Bayoumi, Riad A.L.
AU - Walliker, David
AU - Arnot, David E.
PY - 1991
Y1 - 1991
N2 - Isolates of Plasmodium falciparum from a Sudanese village have been collected as part of a study of parasite genetic diversity during seasonal malaria epidemics. The sensitivity in vitro to chloroquine, pyrimethamine and mefloquine of these isolates has been determined. To assess the utility of pulse field gel chromosome separations in isolate characterization, 18 samples from individual patients in a single village were studied using this technique. Extensive variation in chromosome size was detected, no 2 isolates having identical molecular karyotypes. No multidrug resistance (mdr) gene amplification polymorphisms were detected in either chloroquine-resistant or chloroquine-sensitive isolates in this sample.
AB - Isolates of Plasmodium falciparum from a Sudanese village have been collected as part of a study of parasite genetic diversity during seasonal malaria epidemics. The sensitivity in vitro to chloroquine, pyrimethamine and mefloquine of these isolates has been determined. To assess the utility of pulse field gel chromosome separations in isolate characterization, 18 samples from individual patients in a single village were studied using this technique. Extensive variation in chromosome size was detected, no 2 isolates having identical molecular karyotypes. No multidrug resistance (mdr) gene amplification polymorphisms were detected in either chloroquine-resistant or chloroquine-sensitive isolates in this sample.
UR - http://www.scopus.com/inward/record.url?scp=0025990612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025990612&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(91)90349-4
DO - 10.1016/0035-9203(91)90349-4
M3 - Article
C2 - 1780979
AN - SCOPUS:0025990612
SN - 0035-9203
VL - 85
SP - 578
EP - 583
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 5
ER -