Furazolidone concentrations in plasma, milk and some tissues of Nubian goats.

A. I. Mustafa, B. H. Ali, T. Hassan, A. M. Satti

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Abstract

The concentrations of furazolidone (FZ) in plasma and milk were measured in goats treated orally with the drug at a dose of 10 mg kg-1 daily for 5 days. The maximum plasma concentrations obtained were 1.57 +/- 0.52 micrograms ml-1 (n = 5) 8 h after the first dose, and 2.13 +/- 0.11 micrograms ml-1 (n = 4) 6 h after the fifth dose. The maximum milk concentration was 0.88 +/- 0.32 micrograms ml-1 (n = 4) 8 h following the administration of a single dose. Using a colorimetric method, FZ was not detectable in goats' liver or muscle after the recommended therapeutic dose (10 mg kg-1, 5 days). However, using an HPLC method, the drug was detected 24 h after the treatment in the gluteal muscle and liver at concentrations of 0.26 +/- 0.01 microgram g-1 (n = 5) and 0.10 +/- 0.02 microgram g-1 (n = 5), respectively. The drug concentrations decreased significantly (P less than 0.05-0.01) at 3, 5 and 7 days after treatment, and no measurable concentrations were found after 10 days.

Original languageEnglish
Pages (from-to)190-193
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume8
Issue number2
Publication statusPublished - Jun 1985

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ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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