Furazolidone concentrations in plasma, milk and some tissues of Nubian goats

Mustafa, A.I., Ali, B.H., Hassan, T. & Satti, A.M. Furazolidone concentrations in plasma, milk and some tissues of Nubian goats. J. vet. Pharmacol. Therap. 8, 190–193. The concentrations of furazolidone (FZ) in plasma and milk were measured in goats treated orally with the drug at a dose of 10mg kg^‐1 daily for 5 days. The maximum plasma concentrations obtained were 1.57 δ 0.52 μg ml^‐1 (n = 5) 8 h after the first dose, and 2.13 δ 0.11 μg ml^‐1 (n = 4) 6 h after the fifth dose. The maximum milk concentration was 0.88 δ 0.32 μg ml^‐1 (n = 4) 8h following the administration of a single dose. Using a colorimetric method, FZ was not detectable in goats' liver or muscle after the recommended therapeutic dose (10 mgkg^‐1, 5 days). However, using an HPLC method, the drug was detected 24 h after the treatment in the gluteal muscle and liver at concentrations of 0.2G δ 0.01 μg g^‐1 (n = 5) and 0.10 δ 0.02μg g^_1 (n = 5), respectively. The drug concentrations decreased significantly (P < 0.05‐0.01) at 3, 5 and 7 days after treatment, and no measurable concentrations were found after 10 days. A. I. MustafaC, Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, P.O. Box 32, Khartoum North, Sudan.