Abstract
A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.
Original language | English |
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Pages (from-to) | 6739-6742 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 50 |
DOIs | |
Publication status | Published - Dec 12 2012 |
Keywords
- Anthraquinone
- Cancer
- Cardiovascular
- Deamination
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry