Abstract
A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 6739-6742 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 53 |
| Issue number | 50 |
| DOIs | |
| Publication status | Published - Dec 12 2012 |
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Keywords
- Anthraquinone
- Cancer
- Cardiovascular
- Deamination
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity. / Baqi, Younis; Müller, Christa E.
In: Tetrahedron Letters, Vol. 53, No. 50, 12.12.2012, p. 6739-6742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity
AU - Baqi, Younis
AU - Müller, Christa E.
PY - 2012/12/12
Y1 - 2012/12/12
N2 - A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.
AB - A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.
KW - Anthraquinone
KW - Cancer
KW - Cardiovascular
KW - Deamination
UR - http://www.scopus.com/inward/record.url?scp=84868605609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868605609&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2012.09.011
DO - 10.1016/j.tetlet.2012.09.011
M3 - Article
VL - 53
SP - 6739
EP - 6742
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 50
ER -