Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity

Younis Baqi, Christa E. Müller

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.

Original languageEnglish
Pages (from-to)6739-6742
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number50
DOIs
Publication statusPublished - Dec 12 2012

Fingerprint

Anthraquinones
Deamination
Bioactivity
Libraries
Derivatives
Zinc
Ethanol
Cardiovascular Diseases
Salts
Pharmacology
1-aminoanthraquinone
Pharmaceutical Preparations
Neoplasms

Keywords

  • Anthraquinone
  • Cancer
  • Cardiovascular
  • Deamination

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity. / Baqi, Younis; Müller, Christa E.

In: Tetrahedron Letters, Vol. 53, No. 50, 12.12.2012, p. 6739-6742.

Research output: Contribution to journalArticle

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