Efficient and mild deamination procedure for 1-aminoanthraquinones yielding a diverse library of novel derivatives with potential biological activity

Younis Baqi*, Christa E. Müller

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

14 اقتباسات (Scopus)

ملخص

A convenient in situ method is described for reductive removal of the amino group in position 1 of the anthraquinone (AQ) moiety. The reaction proceeds smoothly within a few minutes yielding novel AQ derivatives in excellent yields. Diazonium salt formation is followed by reduction with zinc in ethanol. The method has been applied to a variety of 1-amino-AQ derivatives. It allows access to a large library of new AQ derivatives which possess potential as pharmacological tools for studying purinergic signaling, and as potential drugs, for example, for the treatment of cancer and cardiovascular diseases.

اللغة الأصليةEnglish
الصفحات (من إلى)6739-6742
عدد الصفحات4
دوريةTetrahedron Letters
مستوى الصوت53
رقم الإصدار50
المعرِّفات الرقمية للأشياء
حالة النشرPublished - ديسمبر 12 2012

ASJC Scopus subject areas

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