Ecthyma contagiosum (orf) - Report of a human case from the United Arab Emirates and review of the literature

Suhail Al-Salam, Norbert Nowotny, Mohammed Rizwan Sohail, Jolanta Kolodziejek, Thomas G. Berger

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Ecthyma contagiosum (orf) is caused by an epitheliotropic parapox virus. It is a zoonosis usually transmitted to humans from affected sheep or goat through direct contact or contaminated fomites. Methods: We report a 36-year-old patient with multiple skin lesions on his left hand, first observed 5 days before admission followed by red streaks on the forearm and an erythema on the upper arm 1 day prior to admission. The patient reported that he was working on a sheep farm. Results: Histopathologic examination showed evidence of a viral infection. Subsequent transmission electron microscopy showed typical parapox virus particles, predominantly in the scaled-off layers of degenerated keratinocytes and monocytes. The results were verified and specified by two newly established polymerase chain reaction (PCR) assays and subsequent sequencing of the amplicons: one broadly reacting 'general parapox virus PCR', and one assay which allows - following sequencing - discrimination between individual orf virus strains. Conclusion: Despite the multiplicity of the lesions, there was a significant improvement after 2 weeks of treatment. Sequencing showed the uniqueness of this virus compared with previously published strains from other countries.

Original languageEnglish
Pages (from-to)603-607
Number of pages5
JournalJournal of Cutaneous Pathology
Volume35
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Ecthyma
Contagious Ecthyma
United Arab Emirates
Viruses
Sheep
Orf virus
Fomites
Polymerase Chain Reaction
Zoonoses
Virus Diseases
Erythema
Transmission Electron Microscopy
Keratinocytes
Forearm
Goats
Virion
Monocytes
Arm
Hand
Skin

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Ecthyma contagiosum (orf) - Report of a human case from the United Arab Emirates and review of the literature. / Al-Salam, Suhail; Nowotny, Norbert; Sohail, Mohammed Rizwan; Kolodziejek, Jolanta; Berger, Thomas G.

In: Journal of Cutaneous Pathology, Vol. 35, No. 6, 06.2008, p. 603-607.

Research output: Contribution to journalArticle

Al-Salam, Suhail ; Nowotny, Norbert ; Sohail, Mohammed Rizwan ; Kolodziejek, Jolanta ; Berger, Thomas G. / Ecthyma contagiosum (orf) - Report of a human case from the United Arab Emirates and review of the literature. In: Journal of Cutaneous Pathology. 2008 ; Vol. 35, No. 6. pp. 603-607.
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