TY - JOUR
T1 - Diffusion NMR Spectroscopy for the Characterization of the Size and Interactions of Colloidal Matter
T2 - The Case of Vesicles and Nanoparticles
AU - Valentini, Massimiliano
AU - Vaccaro, Andrea
AU - Rehor, Annemie
AU - Napoli, Alessandro
AU - Hubbell, Jeffrey A.
AU - Tirelli, Nicola
PY - 2004/2/25
Y1 - 2004/2/25
N2 - We report the application of the pulse gradient spin-echo (PGSE) NMR technique (PGSE NMR) to the analysis of large colloidal materials, specifically vesicles formed from macromolecular amphiphiles and nanoparticles. Measurements of size and size distribution were demonstrated to be comparable to those obtained through dynamic light scattering or hydrodynamic chromatography. In comparison to these more common analytical methods, the use of PGSE NMR is particularly advantageous in that, as a spectroscopic technique, it adds chemical selectivity to the study of physical dimensions. In this way, chemically different species contemporarily present in a sample may be individually studied. In addition, we demonstrate the use of PGSE NMR to probe the existence of equilibria between macroamphiphiles present in solution and those present in vesicles or on the surface of nanoparticles. This feature in particular opens exciting possibilities for the characterization of the phase behavior and of the surface adsorption phenomena of colloids.
AB - We report the application of the pulse gradient spin-echo (PGSE) NMR technique (PGSE NMR) to the analysis of large colloidal materials, specifically vesicles formed from macromolecular amphiphiles and nanoparticles. Measurements of size and size distribution were demonstrated to be comparable to those obtained through dynamic light scattering or hydrodynamic chromatography. In comparison to these more common analytical methods, the use of PGSE NMR is particularly advantageous in that, as a spectroscopic technique, it adds chemical selectivity to the study of physical dimensions. In this way, chemically different species contemporarily present in a sample may be individually studied. In addition, we demonstrate the use of PGSE NMR to probe the existence of equilibria between macroamphiphiles present in solution and those present in vesicles or on the surface of nanoparticles. This feature in particular opens exciting possibilities for the characterization of the phase behavior and of the surface adsorption phenomena of colloids.
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U2 - 10.1021/ja037247r
DO - 10.1021/ja037247r
M3 - Article
C2 - 14971949
AN - SCOPUS:1242342169
SN - 0002-7863
VL - 126
SP - 2142
EP - 2147
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 7
ER -