Diffusion NMR Spectroscopy for the Characterization of the Size and Interactions of Colloidal Matter: The Case of Vesicles and Nanoparticles

Massimiliano Valentini, Andrea Vaccaro, Annemie Rehor, Alessandro Napoli, Jeffrey A. Hubbell, Nicola Tirelli*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

79 اقتباسات (Scopus)

ملخص

We report the application of the pulse gradient spin-echo (PGSE) NMR technique (PGSE NMR) to the analysis of large colloidal materials, specifically vesicles formed from macromolecular amphiphiles and nanoparticles. Measurements of size and size distribution were demonstrated to be comparable to those obtained through dynamic light scattering or hydrodynamic chromatography. In comparison to these more common analytical methods, the use of PGSE NMR is particularly advantageous in that, as a spectroscopic technique, it adds chemical selectivity to the study of physical dimensions. In this way, chemically different species contemporarily present in a sample may be individually studied. In addition, we demonstrate the use of PGSE NMR to probe the existence of equilibria between macroamphiphiles present in solution and those present in vesicles or on the surface of nanoparticles. This feature in particular opens exciting possibilities for the characterization of the phase behavior and of the surface adsorption phenomena of colloids.

اللغة الأصليةEnglish
الصفحات (من إلى)2142-2147
عدد الصفحات6
دوريةJournal of the American Chemical Society
مستوى الصوت126
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 25 2004
منشور خارجيًانعم

ASJC Scopus subject areas

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بصمة

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