Demonstration of hypoperfusion surrounding intracerebral hematoma in humans

Cynthia Sills, Carlos Villar-Cordova, William Pasteur, Ariel Ramirez, Lamk Lamki, Bruce Barron, Nizar Mullani, James Grotta

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We undertook this study to determine whether ischemic regions are present that may contribute to poor outcome after intracerebral hemorrhage (ICH) in humans. Hypoperfusion around an ICH has not been reported in humans. Brain computed tomography (CT) and 99mTc-HMPAO brain single photon emission computed tomography (SPECT) perfusion studies were carried out 51 ± 12 hours after supratentorial ICH in seven patients selected from a referral hospital over an 8-month period. The widest diameters of the hematoma on CT and of reduced perfusion on SPECT were measured and compared. The diameters of reduced perfusion were measured at the 40% and 20% reduced count levels compared with the contralateral side. Reduced perfusion in and around the hematoma was seen in all seven cases. The diameters of ICH on CT (mean, 53 ± 12 mm) were comparable to the diameters of 40% reduction of counts (mean, 61 ± 14 mm) measured by SPECT. The mean diameter of brain demonstrating 20% reduction in counts was 76±19 mm, which was 43% greater than the hematoma diameter on CT (p = .004). In conclusion, substantial regions of reduced perfusion surround ICH in humans, which might contribute to poor outcome and be amenable to anti-ischemic therapy.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume6
Issue number1
DOIs
Publication statusPublished - Sep 1996

Fingerprint

Cerebral Hemorrhage
Hematoma
Perfusion
Single-Photon Emission-Computed Tomography
Tomography
Brain
Technetium Tc 99m Exametazime
Referral and Consultation

Keywords

  • Blood flow
  • Cerebral hemorrhage
  • Ischemia
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine

Cite this

Demonstration of hypoperfusion surrounding intracerebral hematoma in humans. / Sills, Cynthia; Villar-Cordova, Carlos; Pasteur, William; Ramirez, Ariel; Lamki, Lamk; Barron, Bruce; Mullani, Nizar; Grotta, James.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 6, No. 1, 09.1996, p. 17-24.

Research output: Contribution to journalArticle

Sills, C, Villar-Cordova, C, Pasteur, W, Ramirez, A, Lamki, L, Barron, B, Mullani, N & Grotta, J 1996, 'Demonstration of hypoperfusion surrounding intracerebral hematoma in humans', Journal of Stroke and Cerebrovascular Diseases, vol. 6, no. 1, pp. 17-24. https://doi.org/10.1016/S1052-3057(96)80021-8
Sills, Cynthia ; Villar-Cordova, Carlos ; Pasteur, William ; Ramirez, Ariel ; Lamki, Lamk ; Barron, Bruce ; Mullani, Nizar ; Grotta, James. / Demonstration of hypoperfusion surrounding intracerebral hematoma in humans. In: Journal of Stroke and Cerebrovascular Diseases. 1996 ; Vol. 6, No. 1. pp. 17-24.
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