TY - JOUR
T1 - Demonstration of hypoperfusion surrounding intracerebral hematoma in humans
AU - Sills, Cynthia
AU - Villar-Cordova, Carlos
AU - Pasteur, William
AU - Ramirez, Ariel
AU - Lamki, Lamk
AU - Barron, Bruce
AU - Mullani, Nizar
AU - Grotta, James
PY - 1996/9
Y1 - 1996/9
N2 - We undertook this study to determine whether ischemic regions are present that may contribute to poor outcome after intracerebral hemorrhage (ICH) in humans. Hypoperfusion around an ICH has not been reported in humans. Brain computed tomography (CT) and 99mTc-HMPAO brain single photon emission computed tomography (SPECT) perfusion studies were carried out 51 ± 12 hours after supratentorial ICH in seven patients selected from a referral hospital over an 8-month period. The widest diameters of the hematoma on CT and of reduced perfusion on SPECT were measured and compared. The diameters of reduced perfusion were measured at the 40% and 20% reduced count levels compared with the contralateral side. Reduced perfusion in and around the hematoma was seen in all seven cases. The diameters of ICH on CT (mean, 53 ± 12 mm) were comparable to the diameters of 40% reduction of counts (mean, 61 ± 14 mm) measured by SPECT. The mean diameter of brain demonstrating 20% reduction in counts was 76±19 mm, which was 43% greater than the hematoma diameter on CT (p = .004). In conclusion, substantial regions of reduced perfusion surround ICH in humans, which might contribute to poor outcome and be amenable to anti-ischemic therapy.
AB - We undertook this study to determine whether ischemic regions are present that may contribute to poor outcome after intracerebral hemorrhage (ICH) in humans. Hypoperfusion around an ICH has not been reported in humans. Brain computed tomography (CT) and 99mTc-HMPAO brain single photon emission computed tomography (SPECT) perfusion studies were carried out 51 ± 12 hours after supratentorial ICH in seven patients selected from a referral hospital over an 8-month period. The widest diameters of the hematoma on CT and of reduced perfusion on SPECT were measured and compared. The diameters of reduced perfusion were measured at the 40% and 20% reduced count levels compared with the contralateral side. Reduced perfusion in and around the hematoma was seen in all seven cases. The diameters of ICH on CT (mean, 53 ± 12 mm) were comparable to the diameters of 40% reduction of counts (mean, 61 ± 14 mm) measured by SPECT. The mean diameter of brain demonstrating 20% reduction in counts was 76±19 mm, which was 43% greater than the hematoma diameter on CT (p = .004). In conclusion, substantial regions of reduced perfusion surround ICH in humans, which might contribute to poor outcome and be amenable to anti-ischemic therapy.
KW - Blood flow
KW - Cerebral hemorrhage
KW - Ischemia
KW - Single photon emission computed tomography
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UR - http://www.scopus.com/inward/citedby.url?scp=0002869358&partnerID=8YFLogxK
U2 - 10.1016/S1052-3057(96)80021-8
DO - 10.1016/S1052-3057(96)80021-8
M3 - Article
C2 - 17894960
AN - SCOPUS:0002869358
SN - 1052-3057
VL - 6
SP - 17
EP - 24
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 1
ER -