Current views on the population structure of Plasmodium falciparum

Implications for control

Hamza A. Babiker, David Walliker

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalParasitology Today
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 1997

Fingerprint

Plasmodium falciparum
Parasites
Malaria
Population
Malaria Vaccines
Genetic Structures
Antimalarials
Population Genetics
Culicidae
Epidemiology
Clone Cells
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Parasitology

Cite this

Current views on the population structure of Plasmodium falciparum : Implications for control. / Babiker, Hamza A.; Walliker, David.

In: Parasitology Today, Vol. 13, No. 7, 07.1997, p. 262-267.

Research output: Contribution to journalArticle

@article{99aaf3f7599b4b1cba7bf76f0b238d5f,
title = "Current views on the population structure of Plasmodium falciparum: Implications for control",
abstract = "In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.",
author = "Babiker, {Hamza A.} and David Walliker",
year = "1997",
month = "7",
doi = "10.1016/S0169-4758(97)01075-2",
language = "English",
volume = "13",
pages = "262--267",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Current views on the population structure of Plasmodium falciparum

T2 - Implications for control

AU - Babiker, Hamza A.

AU - Walliker, David

PY - 1997/7

Y1 - 1997/7

N2 - In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.

AB - In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.

UR - http://www.scopus.com/inward/record.url?scp=0030797357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030797357&partnerID=8YFLogxK

U2 - 10.1016/S0169-4758(97)01075-2

DO - 10.1016/S0169-4758(97)01075-2

M3 - Article

VL - 13

SP - 262

EP - 267

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 7

ER -