TY - JOUR
T1 - Current views on the population structure of Plasmodium falciparum
T2 - Implications for control
AU - Babiker, Hamza A.
AU - Walliker, David
N1 - Funding Information:
We are g,~teful to the Medical Research Council of Great Britain and the Wellcome Trust for support We thank Margaret Mackinnon for much helpful discussion and editing of previous versions of this paper which have helped to refine the ideas presented. We thank many colleagues, especially Lisa Ranford-Cartwnght, W.G. Hill, G. Beale, Richard Carter, Jana McBride and David Amot for their contribution to the development of the work presented here.
PY - 1997/7
Y1 - 1997/7
N2 - In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.
AB - In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future deployment of control measures such as antimalarial drugs and possible malaria vaccines.
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U2 - 10.1016/S0169-4758(97)01075-2
DO - 10.1016/S0169-4758(97)01075-2
M3 - Article
C2 - 15275063
AN - SCOPUS:0030797357
SN - 0169-4758
VL - 13
SP - 262
EP - 267
JO - Parasitology Today
JF - Parasitology Today
IS - 7
ER -
