Complex t(8;13;21)(q22;q14;q22)-A Novel Variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML-M2)

Achandira Muthappa Udayakumar, Salam Alkindi, Anil Vasanth Pathare, John Alexander Raeburn

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Variants of the t(8;21)(q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t(8;21)(q22;q22) in acute myeloid leukemia (AML) patients. We report a case of AML-M2 with t(8;13;21)(q22;q14;q22), not reported earlier. Using a dual-color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrate an ETO/AML1 fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosomes 8 and 13, to demonstrate the three-way translocation t(8;13;21)(q22;q14;q22). Involvement of chromosome region 13q14 has never been reported earlier, although region 13q12 as a variant in AML with t(8;21) has been reported earlier. The possible role of genes in this region in leukemogenesis, its response to the treatment and its clinical implications are discussed.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalArchives of Medical Research
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Acute myeloid leukemia
  • Karyotype
  • Leukemia
  • Variant translocation

ASJC Scopus subject areas

  • Medicine(all)

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