TY - JOUR
T1 - Complex t(8;13;21)(q22;q14;q22)-A Novel Variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML-M2)
AU - Udayakumar, Achandira Muthappa
AU - Alkindi, Salam
AU - Pathare, Anil Vasanth
AU - Raeburn, John Alexander
PY - 2008/2
Y1 - 2008/2
N2 - Variants of the t(8;21)(q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t(8;21)(q22;q22) in acute myeloid leukemia (AML) patients. We report a case of AML-M2 with t(8;13;21)(q22;q14;q22), not reported earlier. Using a dual-color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrate an ETO/AML1 fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosomes 8 and 13, to demonstrate the three-way translocation t(8;13;21)(q22;q14;q22). Involvement of chromosome region 13q14 has never been reported earlier, although region 13q12 as a variant in AML with t(8;21) has been reported earlier. The possible role of genes in this region in leukemogenesis, its response to the treatment and its clinical implications are discussed.
AB - Variants of the t(8;21)(q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t(8;21)(q22;q22) in acute myeloid leukemia (AML) patients. We report a case of AML-M2 with t(8;13;21)(q22;q14;q22), not reported earlier. Using a dual-color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrate an ETO/AML1 fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosomes 8 and 13, to demonstrate the three-way translocation t(8;13;21)(q22;q14;q22). Involvement of chromosome region 13q14 has never been reported earlier, although region 13q12 as a variant in AML with t(8;21) has been reported earlier. The possible role of genes in this region in leukemogenesis, its response to the treatment and its clinical implications are discussed.
KW - Acute myeloid leukemia
KW - Karyotype
KW - Leukemia
KW - Variant translocation
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U2 - 10.1016/j.arcmed.2007.09.002
DO - 10.1016/j.arcmed.2007.09.002
M3 - Article
C2 - 18164974
AN - SCOPUS:37449000879
SN - 0188-4409
VL - 39
SP - 252
EP - 256
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 2
ER -