Complex t(8;13;21)(q22;q14;q22)-A Novel Variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML-M2)

Achandira Muthappa Udayakumar*, Salam Alkindi, Anil Vasanth Pathare, John Alexander Raeburn

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

22 اقتباسات (Scopus)

ملخص

Variants of the t(8;21)(q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t(8;21)(q22;q22) in acute myeloid leukemia (AML) patients. We report a case of AML-M2 with t(8;13;21)(q22;q14;q22), not reported earlier. Using a dual-color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrate an ETO/AML1 fusion signal on the derivative chromosome 8. Whole chromosome painting probes were used for chromosomes 8 and 13, to demonstrate the three-way translocation t(8;13;21)(q22;q14;q22). Involvement of chromosome region 13q14 has never been reported earlier, although region 13q12 as a variant in AML with t(8;21) has been reported earlier. The possible role of genes in this region in leukemogenesis, its response to the treatment and its clinical implications are discussed.

اللغة الأصليةEnglish
الصفحات (من إلى)252-256
عدد الصفحات5
دوريةArchives of Medical Research
مستوى الصوت39
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 2008

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “Complex t(8;13;21)(q22;q14;q22)-A Novel Variant of t(8;21) in a Patient with Acute Myeloid Leukemia (AML-M2)'. فهما يشكلان معًا بصمة فريدة.

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