Bioactive Constituents of Pulicaria jaubertii: A promising antihypertensive activity

El Sayed M. El-Ghaly, Usama Shaheen*, Ehab Ragab, Atef Ahmed El-Hila, Mohamed Raafat Abd-Allah

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: Phytochemical investigation and evaluation of antihypertensive activity of the alcoholic extract of Pulicaria jaubertii aerial parts. Material and Methods: The chloroform and ethyl acetate fractions were chromatographed on silica gel and sephadex LH 20 to afford six compounds. Their structures were elucidated on the bases of extensive NMR (1H, 13C, DEPT, COSY, HSQC, HMBC, NOESY) and MS analysis. The antihypertensive activity of the alcoholic extract was evaluated against L-NAME-induced hypertensive rats. Results: One new monoterpene glucoside; (2R, 4S)-p-menth-1-ene-2-O-b-D-glucopyranoside [1] along with five known compounds; thymoquinol 2-O-b-D-glucopyranoside (zataroside-B) [2], quercetin 7, β-di-Omethylether (rhamnazin) [3], quercetin 7-O-methylether (rhamnetin) [4], quercetin β-O-methylether (isorhamnetin) [5] and stigmasterol 3-Ob-D-glucopyranoside [6] were isolated. The alcoholic extract significantly reduced the elevated SBP and partially restored the diminished nitric oxide metabolites. Conclusion: Compound [1] is a new and compounds [2-6] are reported for first time from Pulicaria jaubertii. The possible antihypertensive activity of the alcoholic extract may be due to its flavonoids and phenolic contents.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalPharmacognosy Journal
Volume8
Issue number1
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Antihypertensive activity
  • Flavonoids
  • Monoterpene glucoside
  • Nitric oxide
  • Pulicaria jaubertii

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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