Antiviral effects of statins

Armita M. Gorabi, Nasim Kiaie, Vanessa Bianconi, Tannaz Jamialahmadi, Khalid Al-Rasadi, Thomas P. Johnston, Matteo Pirro*, Amirhossein Sahebkar

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

Original languageEnglish
Article number101054
JournalProgress in Lipid Research
Volume79
DOIs
Publication statusPublished - Jul 1 2020
Externally publishedYes

Keywords

  • Cholesterol
  • Infection
  • Pleiotropic
  • Statins
  • Virus

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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