TY - JOUR
T1 - Antiviral effects of statins
AU - Gorabi, Armita M.
AU - Kiaie, Nasim
AU - Bianconi, Vanessa
AU - Jamialahmadi, Tannaz
AU - Al-Rasadi, Khalid
AU - Johnston, Thomas P.
AU - Pirro, Matteo
AU - Sahebkar, Amirhossein
N1 - Copyright © 2020. Published by Elsevier Ltd.
PY - 2020/1
Y1 - 2020/1
N2 - Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.
AB - Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.
KW - Cholesterol
KW - Infection
KW - Pleiotropic
KW - Statins
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85089470678&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089470678&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/a051a66e-ade4-32fb-aeb6-080ebe1bc175/
U2 - 10.1016/j.plipres.2020.101054
DO - 10.1016/j.plipres.2020.101054
M3 - Review article
C2 - 32777243
AN - SCOPUS:85089470678
SN - 0163-7827
VL - 79
SP - 101054
JO - Progress in Lipid Research
JF - Progress in Lipid Research
M1 - 101054
ER -