Antioxidant action of extract of the traditional medicinal plant Rhazya stricta decne. in rats

B. H. Ali*, A. A. Alqarawi, A. K. Bashir, M. O. Tanira

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose. The plant extract, at a dose of 0.25 g/kg, did not significantly affect the concentrations of GSH, LP or AA in the liver or kidneys. At a dose of 1.0 g/kg, the plant extract significantly increased the GSH concentration in the liver, but did not affect the GSH concentration in the kidneys, or LP or AA in the liver or kidneys. The plant extract (4.0 g/kg) significantly increased the GSH and decreased LP peroxidation, but did not affect the AA concentrations in the liver and kidneys. It may be concluded that the R. stricta extract, at some of the doses used, has antioxidant actions in the rat. (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)469-471
Number of pages3
JournalPhytotherapy Research
Volume14
Issue number6
DOIs
Publication statusPublished - 2000

Keywords

  • Ascorbic acid
  • Glutathione
  • Lipid peroxidation
  • Rhazya stricta

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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