TY - JOUR
T1 - Antioxidant action of extract of the traditional medicinal plant Rhazya stricta decne. in rats
AU - Ali, B. H.
AU - Alqarawi, A. A.
AU - Bashir, A. K.
AU - Tanira, M. O.
PY - 2000
Y1 - 2000
N2 - The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose. The plant extract, at a dose of 0.25 g/kg, did not significantly affect the concentrations of GSH, LP or AA in the liver or kidneys. At a dose of 1.0 g/kg, the plant extract significantly increased the GSH concentration in the liver, but did not affect the GSH concentration in the kidneys, or LP or AA in the liver or kidneys. The plant extract (4.0 g/kg) significantly increased the GSH and decreased LP peroxidation, but did not affect the AA concentrations in the liver and kidneys. It may be concluded that the R. stricta extract, at some of the doses used, has antioxidant actions in the rat. (C) 2000 John Wiley and Sons, Ltd.
AB - The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose. The plant extract, at a dose of 0.25 g/kg, did not significantly affect the concentrations of GSH, LP or AA in the liver or kidneys. At a dose of 1.0 g/kg, the plant extract significantly increased the GSH concentration in the liver, but did not affect the GSH concentration in the kidneys, or LP or AA in the liver or kidneys. The plant extract (4.0 g/kg) significantly increased the GSH and decreased LP peroxidation, but did not affect the AA concentrations in the liver and kidneys. It may be concluded that the R. stricta extract, at some of the doses used, has antioxidant actions in the rat. (C) 2000 John Wiley and Sons, Ltd.
KW - Ascorbic acid
KW - Glutathione
KW - Lipid peroxidation
KW - Rhazya stricta
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U2 - 10.1002/1099-1573(200009)14:6<469::AID-PTR612>3.0.CO;2-W
DO - 10.1002/1099-1573(200009)14:6<469::AID-PTR612>3.0.CO;2-W
M3 - Article
C2 - 10960906
AN - SCOPUS:0033822412
SN - 0951-418X
VL - 14
SP - 469
EP - 471
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 6
ER -