The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles

Gentamicin (G) treatment (5, 20, 40 and 80 mg kg^-1 day^-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg^-1, intraperitoneally).