The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles

F. M. El-Sabban, B. H. Ali, A. K. Bashir, M. O M Tanira

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Gentamicin (G) treatment (5, 20, 40 and 80 mg kg-1 day-1 given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P <0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg-1, intraperitoneally).

Original languageEnglish
Pages (from-to)1361-1369
Number of pages9
JournalLife Sciences
Volume62
Issue number15
DOIs
Publication statusPublished - Mar 6 1998

Keywords

  • Acetylsalicylic acid
  • Gentamicin
  • Mice
  • Pial circulation
  • Platelet aggregation

ASJC Scopus subject areas

  • Pharmacology

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