Selective anti-cancer activity against melanoma cells using 3-O-acetyl-β-boswellic acid-loaded 3D-Printed scaffold

Fatemeh Jamshidi-adegani, Saeid Vakilian, Sulaiman Al-Hashmi*, Juhaina Al-Kindi, Najeeb Ur Rehman, Yaqeen Al-Sinani, Shokoofeh Ghaemi, Khurshid Alam, Muhammad U. Anwar, Rene Csuk, Ahmed Al-Harrasi

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

ملخص

This study aimed to develop a local 3 D-printed bioactive graft using poly-caprolacton (PCL) as a drug carrier and 3-O-acetyl-β-boswellic acid (β-ABA) as an anticancer compound. β-ABA-loaded 3 D-printed scaffold was fabricated and physically characterized. The results indicated more desirable mechanical and physical properties of the β-ABA-loaded PCL mat in comparison with the PCL scaffold. Following sustained release of β-ABA, the β-ABA-loaded PCL scaffold revealed selective cytotoxic activity against melanoma cells, while the PCL + ABA with the bolus delivery of β-ABA was toxic against fibroblast cells. Followed by the induction of apoptosis in melanoma cells at the gene level, the result of the western blot showed that the β-ABA-loaded scaffold significantly up-regulated P53 and down-regulated BCL2, with an increment in the ratio of Bax/BCL2. The selective anti-cancer properties of β-ABA-loaded 3 D printed scaffold against melanoma cells indicated that this scaffold could be potentially used as a bioactive graft to improve the melanoma treatment.

اللغة الأصليةEnglish
دوريةNatural Product Research
المعرِّفات الرقمية للأشياء
حالة النشرAccepted/In press - 2022

ASJC Scopus subject areas

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  • ???subjectarea.asjc.1300.1303???
  • ???subjectarea.asjc.1100.1110???
  • ???subjectarea.asjc.1600.1605???

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