@article{9639ec9d2ada48cbb0f097eeaeb63196,
title = "Potential application of crispr/cas9 system to engineer abiotic stress tolerance in plants",
abstract = "Abiotic stresses in plants such as salinity, drought, heavy metal toxicity, heat, and nutrients limitations significantly reduce agricultural production worldwide. The genome editing techniques such as transcriptional activator-like effector nucleases (TALENs) and zinc finger nucleases (ZFNs) have been used for genome manipulations in plants. However, clustered regularly inters-paced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technique has recently emerged as a promising tool for genome editing in plants to acquire desirable traits. The CRISPR/Cas9 system has a great potential to develop crop varieties with improved tolerance against abiotic stresses. This review is centered on the biology and potential application of the CRISPR/Cas9 system to improve abiotic stress tolerance in plants. Furthermore, this review high-lighted the recent advancements of CRISPR/Cas9-mediated genome editing for sustainable agriculture.",
keywords = "Abiotic stresses, CRISPR/Cas9, Crop improvement, Genome editing, SgRNA, Transcription",
author = "Temoor Ahmed and Muhammad Noman and Muhammad Shahid and Sher Muhammad and {Ul Qamar}, {Muhammad Tahir} and Ali, {Md Arshad} and Awais Maqsood and Rahila Hafeez and Ogunyemi, {Solabomi Olaitan} and Bin Li",
note = "Funding Information: This work is financially supported by Shanghai Agriculture Applied Technology Development Program (Grant no. 2019-02-08-00-08-F01150), Zhejiang Provincial Natural Science Foundation of China (LZ19C140002), National Natural Science Foundation of China (Grant nos. 31872017, 32072472, 31571971, 31371904, 31801787, 31901925), Zhejiang Provincial Project (Grant nos. 2017C02002, 2019C02006, 2020C02006), National Key Research and Development Program of China (Grant nos. 2017YFD0201104; 2018YFD0300900), Key Scientific Technological Project of Ningbo (Grant no. 2016C11017), the Fundamental Research Funds for the Central Universities, Dabeinong Funds for Discipline Development and Talent Training in Zhejiang University, State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products (Grant no. 2010DS700124-ZZ2014), Key Research and Development Program of Ningxia Hui Autonomous Region (Grant no 2020BBF03004). Publisher Copyright: {\textcopyright} 2021 Bentham Science Publishers.",
year = "2021",
month = aug,
doi = "10.2174/0929866528666210218220138",
language = "English",
volume = "28",
pages = "861--877",
journal = "Protein and Peptide Letters",
issn = "0929-8665",
publisher = "Bentham Science Publishers B.V.",
number = "8",
}