Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Christa E. Müller; Jamshed Iqbal; Younis Baqi; Herbert Zimmermann; Anita Röllich; Holger Stephan

doi:10.1016/j.bmcl.2006.09.003

Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Christa E. Müller^*, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan

^*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

160 اقتباسات (Scopus)

ملخص

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K₆H₂[TiW₁₁CoO₄₀], exhibiting K_i values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH₄)₁₈[NaSb₉W₂₁O₈₆], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

اللغة الأصلية	English
الصفحات (من إلى)	5943-5947
عدد الصفحات	5
دورية	Bioorganic and Medicinal Chemistry Letters
مستوى الصوت	16
رقم الإصدار	23
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/j.bmcl.2006.09.003
حالة النشر	Published - ديسمبر 1 2006
منشور خارجيًا	نعم

ASJC Scopus subject areas

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أهداف الأمم المتحدة للتنمية المستدامة

يساهم هذا المخرج في تحقيق أهداف الأمم المتحدة للتنمية المستدامة التالية (SDGs)

الوصول إلى المستند

10.1016/j.bmcl.2006.09.003

الملفات والروابط الأخرى

قم بذكر هذا

Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. / Müller, Christa E.; Iqbal, Jamshed; Baqi, Younis وآخرون.
في: Bioorganic and Medicinal Chemistry Letters, المجلد 16, رقم 23, ٠١.١٢.٢٠٠٦, صفحة 5943-5947.

نتاج البحث: المساهمة في مجلة › Article › مراجعة النظراء

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abstract = "Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.",

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T1 - Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

AU - Müller, Christa E.

AU - Iqbal, Jamshed

AU - Baqi, Younis

AU - Zimmermann, Herbert

AU - Röllich, Anita

AU - Stephan, Holger

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

AB - Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

KW - NTPDases

KW - P2 receptors

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Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

ملخص

ASJC Scopus subject areas

أهداف الأمم المتحدة للتنمية المستدامة

الوصول إلى المستند

الملفات والروابط الأخرى

بصمة

قم بذكر هذا