Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Christa E. Müller, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

Original languageEnglish
Pages (from-to)5943-5947
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number23
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • NTPDases
  • P2 receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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