Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Christa E. Müller; Jamshed Iqbal; Younis Baqi; Herbert Zimmermann; Anita Röllich; Holger Stephan

doi:10.1016/j.bmcl.2006.09.003

Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Christa E. Müller^*, Jamshed Iqbal, Younis Baqi, Herbert Zimmermann, Anita Röllich, Holger Stephan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

159 Citations (Scopus)

Abstract

Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K₆H₂[TiW₁₁CoO₄₀], exhibiting K_i values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH₄)₁₈[NaSb₉W₂₁O₈₆], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

Original language	English
Pages (from-to)	5943-5947
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2006.09.003
Publication status	Published - Dec 1 2006
Externally published	Yes

Keywords

NTPDases
P2 receptors

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2006.09.003

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title = "Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors",

abstract = "Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.",

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AU - Müller, Christa E.

AU - Iqbal, Jamshed

AU - Baqi, Younis

AU - Zimmermann, Herbert

AU - Röllich, Anita

AU - Stephan, Holger

PY - 2006/12/1

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N2 - Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

AB - Polyoxotungstates were identified as potent inhibitors of NTPDases1, 2, and 3. The most potent compound was K6H2[TiW11CoO40], exhibiting Ki values of 0.140 μM (NTPDase1), 0.910 μM (NTPDase2), and 0.563 μM (NTPDase3). One of the compounds, (NH4)18[NaSb9W21O86], was selective for NTPDases2 and 3 versus NTPDase1. NTPDase inhibition might contribute to the described biological effects of polyoxometalates, including their anti-cancer activity.

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KW - P2 receptors

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Polyoxometalates-a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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