TY - JOUR
T1 - Metal-catalyzed C–H bond functionalization of phenol derivatives
AU - Al Mamari, Hamad H.
AU - Štefane, Bogdan
AU - Žugelj, Helena Brodnik
N1 - Publisher Copyright:
© 2020
PY - 2020/2/28
Y1 - 2020/2/28
N2 - Phenols and phenol derivatives constitute important starting materials, synthetic intermediates, and functional moieties of a broad range of chemicals and materials. They represent large production products of benzene and benzene oxidation derivatives and are nowadays progressively available from biomass sources. In the last decades or so, there have been tremendous advances in the field of catalytic C–H bond functionalization, among which metal-catalyzed C–H bond functionalization of phenol derivatives plays a substantial role. In this review, the latest transition metal catalyzed C–H bond functionalizations of phenol derivatives are summarized. The presented methods are powerful tools for various C-H fucntionalziation reactions such as arylation, alkenylation, and acylation as well as annulation of phenol derivatives The presented C-H bond functionalziation of phenol derivatives were carried out in a highly step-economical mannerfrom readily available starting materials. Additionally, this review summarizes the main mechanistic aspects of the covered topic.
AB - Phenols and phenol derivatives constitute important starting materials, synthetic intermediates, and functional moieties of a broad range of chemicals and materials. They represent large production products of benzene and benzene oxidation derivatives and are nowadays progressively available from biomass sources. In the last decades or so, there have been tremendous advances in the field of catalytic C–H bond functionalization, among which metal-catalyzed C–H bond functionalization of phenol derivatives plays a substantial role. In this review, the latest transition metal catalyzed C–H bond functionalizations of phenol derivatives are summarized. The presented methods are powerful tools for various C-H fucntionalziation reactions such as arylation, alkenylation, and acylation as well as annulation of phenol derivatives The presented C-H bond functionalziation of phenol derivatives were carried out in a highly step-economical mannerfrom readily available starting materials. Additionally, this review summarizes the main mechanistic aspects of the covered topic.
KW - Bidentate directing groups
KW - Chelation-assistance
KW - C–H bond functionalization
KW - Monodentate directing groups
KW - Phenol derivatives
KW - Transition metals
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U2 - 10.1016/j.tet.2020.130925
DO - 10.1016/j.tet.2020.130925
M3 - Review article
AN - SCOPUS:85078340485
SN - 0040-4020
VL - 76
JO - Tetrahedron
JF - Tetrahedron
IS - 9
M1 - 130925
ER -