Metal-catalyzed C–H bond functionalization of phenol derivatives

Hamad H. Al Mamari*, Bogdan Štefane, Helena Brodnik Žugelj

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Phenols and phenol derivatives constitute important starting materials, synthetic intermediates, and functional moieties of a broad range of chemicals and materials. They represent large production products of benzene and benzene oxidation derivatives and are nowadays progressively available from biomass sources. In the last decades or so, there have been tremendous advances in the field of catalytic C–H bond functionalization, among which metal-catalyzed C–H bond functionalization of phenol derivatives plays a substantial role. In this review, the latest transition metal catalyzed C–H bond functionalizations of phenol derivatives are summarized. The presented methods are powerful tools for various C-H fucntionalziation reactions such as arylation, alkenylation, and acylation as well as annulation of phenol derivatives The presented C-H bond functionalziation of phenol derivatives were carried out in a highly step-economical mannerfrom readily available starting materials. Additionally, this review summarizes the main mechanistic aspects of the covered topic.

Original languageEnglish
Article number130925
Issue number9
Publication statusPublished - Feb 28 2020
Externally publishedYes


  • Bidentate directing groups
  • Chelation-assistance
  • C–H bond functionalization
  • Monodentate directing groups
  • Phenol derivatives
  • Transition metals

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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