Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif Peterson, Richard Gibbs, Marie Claude Gingras, Judith F. Margolin*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

4 اقتباسات (Scopus)

ملخص

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

اللغة الأصليةEnglish
الصفحات (من إلى)629-643
عدد الصفحات15
دوريةPediatric Hematology and Oncology
مستوى الصوت22
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أكتوبر 2005

ASJC Scopus subject areas

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