Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki; Yasser A. Wali; Shah M. Wasifuddin; Mathew Zachariah; Rayhanah Al-Mjeni; Changping Li; Shanmugakonar Muralitharan; Khalsa Al-Kharusi; Preethi Gunaratne; Leif Peterson; Richard Gibbs; Marie Claude Gingras; Judith F. Margolin

doi:10.1080/08880010500199069

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif Peterson, Richard Gibbs, Marie Claude Gingras, Judith F. Margolin

Child Health

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

Original language	English
Pages (from-to)	629-643
Number of pages	15
Journal	Pediatric Hematology and Oncology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1080/08880010500199069
Publication status	Published - Oct 2005

Keywords

ALL
CASK
CRSP2
Gene expression profiling
GZMK

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology
Cancer Research

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10.1080/08880010500199069

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Al-Lamki, Z., Wali, Y. A., Wasifuddin, S. M., Zachariah, M., Al-Mjeni, R., Li, C., Muralitharan, S., Al-Kharusi, K., Gunaratne, P., Peterson, L., Gibbs, R., Gingras, M. C., & Margolin, J. F. (2005). Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. Pediatric Hematology and Oncology, 22(7), 629-643. https://doi.org/10.1080/08880010500199069

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. / Al-Lamki, Zakia ; Wali, Yasser A.; Wasifuddin, Shah M.; Zachariah, Mathew; Al-Mjeni, Rayhanah; Li, Changping; Muralitharan, Shanmugakonar; Al-Kharusi, Khalsa; Gunaratne, Preethi; Peterson, Leif; Gibbs, Richard; Gingras, Marie Claude; Margolin, Judith F.

In: Pediatric Hematology and Oncology, Vol. 22, No. 7, 10.2005, p. 629-643.

Research output: Contribution to journal › Article

Al-Lamki, Z , Wali, YA, Wasifuddin, SM, Zachariah, M, Al-Mjeni, R, Li, C, Muralitharan, S, Al-Kharusi, K, Gunaratne, P, Peterson, L, Gibbs, R, Gingras, MC & Margolin, JF 2005, 'Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia', Pediatric Hematology and Oncology, vol. 22, no. 7, pp. 629-643. https://doi.org/10.1080/08880010500199069

Al-Lamki, Zakia ; Wali, Yasser A. ; Wasifuddin, Shah M. ; Zachariah, Mathew ; Al-Mjeni, Rayhanah ; Li, Changping ; Muralitharan, Shanmugakonar ; Al-Kharusi, Khalsa ; Gunaratne, Preethi ; Peterson, Leif ; Gibbs, Richard ; Gingras, Marie Claude ; Margolin, Judith F. / Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. In: Pediatric Hematology and Oncology. 2005 ; Vol. 22, No. 7. pp. 629-643.

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