TY - JOUR
T1 - Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia
AU - Al-Lamki, Zakia
AU - Wali, Yasser A.
AU - Wasifuddin, Shah M.
AU - Zachariah, Mathew
AU - Al-Mjeni, Rayhanah
AU - Li, Changping
AU - Muralitharan, Shanmugakonar
AU - Al-Kharusi, Khalsa
AU - Gunaratne, Preethi
AU - Peterson, Leif
AU - Gibbs, Richard
AU - Gingras, Marie Claude
AU - Margolin, Judith F.
PY - 2005/10
Y1 - 2005/10
N2 - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
AB - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
KW - ALL
KW - CASK
KW - CRSP2
KW - Gene expression profiling
KW - GZMK
UR - http://www.scopus.com/inward/record.url?scp=25444523003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444523003&partnerID=8YFLogxK
U2 - 10.1080/08880010500199069
DO - 10.1080/08880010500199069
M3 - Article
C2 - 16166056
AN - SCOPUS:25444523003
VL - 22
SP - 629
EP - 643
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 7
ER -