Abstract
Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
| Original language | English |
|---|---|
| Pages (from-to) | 629-643 |
| Number of pages | 15 |
| Journal | Pediatric Hematology and Oncology |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 2005 |
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Keywords
- ALL
- CASK
- CRSP2
- Gene expression profiling
- GZMK
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
- Cancer Research
Cite this
Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. / Al-Lamki, Zakia; Wali, Yasser A.; Wasifuddin, Shah M.; Zachariah, Mathew; Al-Mjeni, Rayhanah; Li, Changping; Muralitharan, Shanmugakonar; Al-Kharusi, Khalsa; Gunaratne, Preethi; Peterson, Leif; Gibbs, Richard; Gingras, Marie Claude; Margolin, Judith F.
In: Pediatric Hematology and Oncology, Vol. 22, No. 7, 10.2005, p. 629-643.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia
AU - Al-Lamki, Zakia
AU - Wali, Yasser A.
AU - Wasifuddin, Shah M.
AU - Zachariah, Mathew
AU - Al-Mjeni, Rayhanah
AU - Li, Changping
AU - Muralitharan, Shanmugakonar
AU - Al-Kharusi, Khalsa
AU - Gunaratne, Preethi
AU - Peterson, Leif
AU - Gibbs, Richard
AU - Gingras, Marie Claude
AU - Margolin, Judith F.
PY - 2005/10
Y1 - 2005/10
N2 - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
AB - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.
KW - ALL
KW - CASK
KW - CRSP2
KW - Gene expression profiling
KW - GZMK
UR - http://www.scopus.com/inward/record.url?scp=25444523003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444523003&partnerID=8YFLogxK
U2 - 10.1080/08880010500199069
DO - 10.1080/08880010500199069
M3 - Article
C2 - 16166056
AN - SCOPUS:25444523003
VL - 22
SP - 629
EP - 643
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 7
ER -