Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif Peterson, Richard Gibbs, Marie Claude Gingras, Judith F. Margolin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

Original languageEnglish
Pages (from-to)629-643
Number of pages15
JournalPediatric Hematology and Oncology
Volume22
Issue number7
DOIs
Publication statusPublished - Oct 2005

Keywords

  • ALL
  • CASK
  • CRSP2
  • Gene expression profiling
  • GZMK

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Al-Lamki, Z., Wali, Y. A., Wasifuddin, S. M., Zachariah, M., Al-Mjeni, R., Li, C., Muralitharan, S., Al-Kharusi, K., Gunaratne, P., Peterson, L., Gibbs, R., Gingras, M. C., & Margolin, J. F. (2005). Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. Pediatric Hematology and Oncology, 22(7), 629-643. https://doi.org/10.1080/08880010500199069