@article{3a14764663f5489d871fe79951233eeb,
title = "Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia",
abstract = "Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.",
keywords = "ALL, CASK, CRSP2, GZMK, Gene expression profiling",
author = "Zakia Al-Lamki and Wali, {Yasser A.} and Wasifuddin, {Shah M.} and Mathew Zachariah and Rayhanah Al-Mjeni and Changping Li and Shanmugakonar Muralitharan and Khalsa Al-Kharusi and Preethi Gunaratne and Leif Peterson and Richard Gibbs and Gingras, {Marie Claude} and Margolin, {Judith F.}",
note = "Funding Information: Received 18 March 2005; accepted 7 June 2005. Marie-Claude Gingras and Judith F. Margolin shared the direction of this work. This study was supported by a grant from His Majesty Sultan Qaboos{\textquoteright} Strategic Research Trust Fund. We thank Dr. Steuber and the TCCC and SQUH clinical teams for their collaboration. We also acknowledge the contributions of the Baylor College of Medicine–Human Genome Sequencing Center headed by Dr. Gibbs, and the SQU Department of Biochemistry headed by Dr. Bayoumi. Address correspondence to Judith Margolin, MD, Texas Children Hospital, Feigin Center, 6621 Fannin Street, MC3-3320, Houston, TX 77030, USA. E-mail: jfmargol@txccc.org",
year = "2005",
month = oct,
doi = "10.1080/08880010500199069",
language = "English",
volume = "22",
pages = "629--643",
journal = "Pediatric Hematology and Oncology",
issn = "0888-0018",
publisher = "Informa Healthcare",
number = "7",
}