Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki; Yasser A. Wali; Shah M. Wasifuddin; Mathew Zachariah; Rayhanah Al-Mjeni; Changping Li; Shanmugakonar Muralitharan; Khalsa Al-Kharusi; Preethi Gunaratne; Leif Peterson; Richard Gibbs; Marie Claude Gingras; Judith F. Margolin

doi:10.1080/08880010500199069

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Zakia Al-Lamki, Yasser A. Wali, Shah M. Wasifuddin, Mathew Zachariah, Rayhanah Al-Mjeni, Changping Li, Shanmugakonar Muralitharan, Khalsa Al-Kharusi, Preethi Gunaratne, Leif Peterson, Richard Gibbs, Marie Claude Gingras, Judith F. Margolin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

Original language	English
Pages (from-to)	629-643
Number of pages	15
Journal	Pediatric Hematology and Oncology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1080/08880010500199069
Publication status	Published - Oct 2005
Externally published	Yes

Keywords

ALL
CASK
CRSP2
GZMK
Gene expression profiling

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1080/08880010500199069

Cite this

Al-Lamki, Z., Wali, Y. A., Wasifuddin, S. M., Zachariah, M., Al-Mjeni, R., Li, C., Muralitharan, S., Al-Kharusi, K., Gunaratne, P., Peterson, L., Gibbs, R., Gingras, M. C., & Margolin, J. F. (2005). Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. Pediatric Hematology and Oncology, 22(7), 629-643. https://doi.org/10.1080/08880010500199069

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. / Al-Lamki, Zakia ; Wali, Yasser A.; Wasifuddin, Shah M.; Zachariah, Mathew; Al-Mjeni, Rayhanah; Li, Changping; Muralitharan, Shanmugakonar; Al-Kharusi, Khalsa; Gunaratne, Preethi; Peterson, Leif; Gibbs, Richard; Gingras, Marie Claude; Margolin, Judith F.

In: Pediatric Hematology and Oncology, Vol. 22, No. 7, 10.2005, p. 629-643.

Research output: Contribution to journal › Article › peer-review

Al-Lamki, Z , Wali, YA, Wasifuddin, SM, Zachariah, M, Al-Mjeni, R, Li, C, Muralitharan, S, Al-Kharusi, K, Gunaratne, P, Peterson, L, Gibbs, R, Gingras, MC & Margolin, JF 2005, 'Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia', Pediatric Hematology and Oncology, vol. 22, no. 7, pp. 629-643. https://doi.org/10.1080/08880010500199069

Al-Lamki, Zakia ; Wali, Yasser A. ; Wasifuddin, Shah M. ; Zachariah, Mathew ; Al-Mjeni, Rayhanah ; Li, Changping ; Muralitharan, Shanmugakonar ; Al-Kharusi, Khalsa ; Gunaratne, Preethi ; Peterson, Leif ; Gibbs, Richard ; Gingras, Marie Claude ; Margolin, Judith F. / Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia. In: Pediatric Hematology and Oncology. 2005 ; Vol. 22, No. 7. pp. 629-643.

@article{3a14764663f5489d871fe79951233eeb,

title = "Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia",

abstract = "Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.",

keywords = "ALL, CASK, CRSP2, GZMK, Gene expression profiling",

author = "Zakia Al-Lamki and Wali, {Yasser A.} and Wasifuddin, {Shah M.} and Mathew Zachariah and Rayhanah Al-Mjeni and Changping Li and Shanmugakonar Muralitharan and Khalsa Al-Kharusi and Preethi Gunaratne and Leif Peterson and Richard Gibbs and Gingras, {Marie Claude} and Margolin, {Judith F.}",

note = "Funding Information: Received 18 March 2005; accepted 7 June 2005. Marie-Claude Gingras and Judith F. Margolin shared the direction of this work. This study was supported by a grant from His Majesty Sultan Qaboos{\textquoteright} Strategic Research Trust Fund. We thank Dr. Steuber and the TCCC and SQUH clinical teams for their collaboration. We also acknowledge the contributions of the Baylor College of Medicine–Human Genome Sequencing Center headed by Dr. Gibbs, and the SQU Department of Biochemistry headed by Dr. Bayoumi. Address correspondence to Judith Margolin, MD, Texas Children Hospital, Feigin Center, 6621 Fannin Street, MC3-3320, Houston, TX 77030, USA. E-mail: jfmargol@txccc.org",

year = "2005",

month = oct,

doi = "10.1080/08880010500199069",

language = "English",

volume = "22",

pages = "629--643",

journal = "Pediatric Hematology and Oncology",

issn = "0888-0018",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

AU - Al-Lamki, Zakia

AU - Wali, Yasser A.

AU - Wasifuddin, Shah M.

AU - Zachariah, Mathew

AU - Al-Mjeni, Rayhanah

AU - Li, Changping

AU - Muralitharan, Shanmugakonar

AU - Al-Kharusi, Khalsa

AU - Gunaratne, Preethi

AU - Peterson, Leif

AU - Gibbs, Richard

AU - Gingras, Marie Claude

AU - Margolin, Judith F.

N1 - Funding Information: Received 18 March 2005; accepted 7 June 2005. Marie-Claude Gingras and Judith F. Margolin shared the direction of this work. This study was supported by a grant from His Majesty Sultan Qaboos’ Strategic Research Trust Fund. We thank Dr. Steuber and the TCCC and SQUH clinical teams for their collaboration. We also acknowledge the contributions of the Baylor College of Medicine–Human Genome Sequencing Center headed by Dr. Gibbs, and the SQU Department of Biochemistry headed by Dr. Bayoumi. Address correspondence to Judith Margolin, MD, Texas Children Hospital, Feigin Center, 6621 Fannin Street, MC3-3320, Houston, TX 77030, USA. E-mail: jfmargol@txccc.org

PY - 2005/10

Y1 - 2005/10

N2 - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

AB - Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

KW - ALL

KW - CASK

KW - CRSP2

KW - GZMK

KW - Gene expression profiling

UR - http://www.scopus.com/inward/record.url?scp=25444523003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444523003&partnerID=8YFLogxK

U2 - 10.1080/08880010500199069

DO - 10.1080/08880010500199069

M3 - Article

C2 - 16166056

AN - SCOPUS:25444523003

VL - 22

SP - 629

EP - 643

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

SN - 0888-0018

IS - 7

ER -

Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this