TY - JOUR
T1 - First cytogenetic profile of Omani patients with de novo myelodysplastic syndromes
T2 - Comparison with data from Asia, Africa, Europe and North and South America
AU - Udayakumar, Achandira M.
AU - Fawaz, Nagla
AU - Pathare, Anil
AU - Asraf, Shakila
AU - Al-Huneini, Mohammed
AU - Al-Farsi, Khalil
AU - Al-Kindi, Salam
AU - Al-Khabouri, Murtadha
N1 - Publisher Copyright:
© 2017, Sultan Qaboos University. All rights reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.
AB - Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.
KW - Chromosomal aberrations
KW - Cytogenetic abnormalities
KW - Ethnic groups
KW - Myelodysplastic syndromes
KW - Oman
KW - Population heterogeneity
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U2 - 10.18295/squmj.2017.17.03.005
DO - 10.18295/squmj.2017.17.03.005
M3 - Article
C2 - 29062550
AN - SCOPUS:85031313087
SN - 2075-051X
VL - 17
SP - e286-e292
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 3
ER -