First cytogenetic profile of Omani patients with de novo myelodysplastic syndromes: Comparison with data from Asia, Africa, Europe and North and South America

Achandira M. Udayakumar, Nagla Fawaz, Anil Pathare, Shakila Asraf, Mohammed Al-Huneini, Khalil Al-Farsi, Salam Al-Kindi, Murtadha Al-Khabouri

Research output: Contribution to journalArticle

Abstract

Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.

Original languageEnglish
Pages (from-to)e286-e292
JournalSultan Qaboos University Medical Journal
Volume17
Issue number3
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

South America
Myelodysplastic Syndromes
North America
Cytogenetics
Chromosome Aberrations
Oman
Karyotype
Population

Keywords

  • Chromosomal aberrations
  • Cytogenetic abnormalities
  • Ethnic groups
  • Myelodysplastic syndromes
  • Oman
  • Population heterogeneity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

First cytogenetic profile of Omani patients with de novo myelodysplastic syndromes : Comparison with data from Asia, Africa, Europe and North and South America. / Udayakumar, Achandira M.; Fawaz, Nagla; Pathare, Anil; Asraf, Shakila; Al-Huneini, Mohammed; Al-Farsi, Khalil; Al-Kindi, Salam; Al-Khabouri, Murtadha.

In: Sultan Qaboos University Medical Journal, Vol. 17, No. 3, 01.08.2017, p. e286-e292.

Research output: Contribution to journalArticle

@article{9ee907d67b0d470a8cadaeac60247635,
title = "First cytogenetic profile of Omani patients with de novo myelodysplastic syndromes: Comparison with data from Asia, Africa, Europe and North and South America",
abstract = "Clonal cytogenetic abnormalities have been reported among 30–80{\%} of patients with myelodysplastic syndromes (MDS); however, 20–70{\%} of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.",
keywords = "Chromosomal aberrations, Cytogenetic abnormalities, Ethnic groups, Myelodysplastic syndromes, Oman, Population heterogeneity",
author = "Udayakumar, {Achandira M.} and Nagla Fawaz and Anil Pathare and Shakila Asraf and Mohammed Al-Huneini and Khalil Al-Farsi and Salam Al-Kindi and Murtadha Al-Khabouri",
year = "2017",
month = "8",
day = "1",
doi = "10.18295/squmj.2017.17.03.005",
language = "English",
volume = "17",
pages = "e286--e292",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "3",

}

TY - JOUR

T1 - First cytogenetic profile of Omani patients with de novo myelodysplastic syndromes

T2 - Comparison with data from Asia, Africa, Europe and North and South America

AU - Udayakumar, Achandira M.

AU - Fawaz, Nagla

AU - Pathare, Anil

AU - Asraf, Shakila

AU - Al-Huneini, Mohammed

AU - Al-Farsi, Khalil

AU - Al-Kindi, Salam

AU - Al-Khabouri, Murtadha

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.

AB - Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specific chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specific chromosomal aberrations. This article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the first report to describe the cytogenetic data of patients with MDS from Oman.

KW - Chromosomal aberrations

KW - Cytogenetic abnormalities

KW - Ethnic groups

KW - Myelodysplastic syndromes

KW - Oman

KW - Population heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=85031313087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031313087&partnerID=8YFLogxK

U2 - 10.18295/squmj.2017.17.03.005

DO - 10.18295/squmj.2017.17.03.005

M3 - Article

AN - SCOPUS:85031313087

VL - 17

SP - e286-e292

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 3

ER -