TY - JOUR
T1 - EFFECT OF FURAZOLIDONE AND NITROFURAZONE ON BRAIN GAMMA‐AMINO BUTYRIC ACID AND GLUTAMATE CONCENTRATIONS IN CHICKENS
AU - Ali, B. H.
PY - 1989/5
Y1 - 1989/5
N2 - 1. The concentrations of gamma‐amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose‐dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.
AB - 1. The concentrations of gamma‐amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose‐dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.
KW - brain GABA concentrations
KW - chickens
KW - furazolidone
KW - gamma‐amino butyric acid
KW - glutamate
KW - nitrofurazone
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U2 - 10.1111/j.1440-1681.1989.tb01572.x
DO - 10.1111/j.1440-1681.1989.tb01572.x
M3 - Article
C2 - 2766580
AN - SCOPUS:0024348813
SN - 0305-1870
VL - 16
SP - 363
EP - 366
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 5
ER -