EFFECT OF FURAZOLIDONE AND NITROFURAZONE ON BRAIN GAMMA‐AMINO BUTYRIC ACID AND GLUTAMATE CONCENTRATIONS IN CHICKENS

B. H. Ali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. The concentrations of gamma‐amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small dose of FZ or NF and about 18% when on the high doses. 3. Both drugs produced dose‐dependent increases in the concentrations of GABA and glutamate which were statistically significant at doses of 25 and 50 mg/kg of NF, and 50 mg/kg of FZ.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume16
Issue number5
DOIs
Publication statusPublished - May 1989
Externally publishedYes

Keywords

  • brain GABA concentrations
  • chickens
  • furazolidone
  • gamma‐amino butyric acid
  • glutamate
  • nitrofurazone

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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